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🧬 Postdoctoral Fellow – DNA Repair, Structural Biology & Nanobody Engineering | University of South Alabama
Institution: University of South Alabama – Mitchell Cancer Institute, Prakash Lab
📍 Location: Mobile, Alabama, USA
💼 Position Available: Postdoctoral Research Fellow
🔬 Research Area: DNA Repair | Structural Biology | Cancer Biology | Nanobody Engineering | Mitochondrial DNA | Biophysics | Protein Engineering
The Prakash Lab at the Mitchell Cancer Institute, University of South Alabama, is seeking a highly motivated Postdoctoral Research Fellow to join its research program investigating fundamental mechanisms of DNA repair and genome stability.
The research focuses on multiple areas of DNA repair, including Base Excision Repair (BER), Mismatch Repair (MMR), mitochondrial DNA biology, and gene–environment interactions. The successful candidate will also contribute to innovative research involving synthetic-lethal nanobodies and advanced structural and functional approaches.
🔬 What You’ll Work On
DNA Repair Mechanisms
Investigate fundamental mechanisms involved in DNA repair and genome maintenance, with a focus on understanding the molecular processes that protect cellular genetic material.
Base Excision Repair & Mismatch Repair
Study important DNA repair pathways, including:
- Base Excision Repair (BER)
- Mismatch Repair (MMR)
- DNA damage recognition and repair mechanisms
Mitochondrial DNA
Investigate mechanisms associated with mitochondrial DNA maintenance, damage, and repair and their potential biological implications.
Gene–Environment Interactions
Explore how environmental factors and genetic mechanisms interact to influence DNA damage, repair processes, and cellular responses.
Nanobody Engineering
Develop and investigate synthetic-lethal nanobodies as innovative tools for studying molecular pathways and potential therapeutic vulnerabilities.
Structural Biology & Biophysics
Apply structural and biophysical approaches to investigate the molecular mechanisms, interactions, and functions of proteins involved in DNA repair and related biological processes.
🧪 Research Techniques
The successful candidate will have opportunities to work with advanced experimental approaches, including:
- X-ray crystallography
- Structural biology
- Biophysical techniques
- Deep mutational scanning
- Cell-based assays
- Molecular biology approaches
- Protein characterization
- Nanobody engineering
🎯 Ideal Candidates
Applicants should meet the following requirements:
- A PhD in Biochemistry, Molecular Biology, Structural Biology, Biophysics, or a related field.
- Strong background in molecular and biochemical research.
- Interest in DNA repair and genome stability.
- Experience or interest in structural biology and protein characterization.
- Ability to conduct research independently.
- Strong analytical, organizational, and communication skills.
- Ability to work effectively within a collaborative research environment.
Candidates with relevant experience in DNA repair, structural biology, biophysics, protein engineering, or cell-based assays may be particularly well suited to the position.
🌟 What You’ll Gain
- Opportunity to conduct cutting-edge research in DNA repair and genome stability.
- Experience investigating BER, MMR, and mitochondrial DNA biology.
- Training in advanced structural biology and biophysical approaches.
- Hands-on experience with X-ray crystallography and deep mutational scanning.
- Opportunity to contribute to innovative research involving synthetic-lethal nanobodies.
- Experience with molecular, biochemical, and cell-based experimental approaches.
- Opportunity to work within the Mitchell Cancer Institute.
- A collaborative and interdisciplinary research environment.
💼 Position Details
Position: Postdoctoral Research Fellow
Institution: University of South Alabama
Research Institute: Mitchell Cancer Institute
Research Group: Prakash Lab
Location: Mobile, Alabama, USA
Research Focus: DNA Repair | Structural Biology | Nanobody Engineering
Key Research Areas: BER | MMR | Mitochondrial DNA | Gene–Environment Interactions
Research Techniques: X-Ray Crystallography | Biophysics | Deep Mutational Scanning | Cell Assays
Start Date: Flexible
Application Review: Immediate and ongoing
🧬 Research Focus
The Prakash Lab investigates fundamental biological mechanisms associated with DNA damage, repair, and genome stability.
The broader research areas include:
- Base Excision Repair (BER)
- Mismatch Repair (MMR)
- DNA damage and repair
- Mitochondrial DNA biology
- Gene–environment interactions
- Structural biology
- Protein biophysics
- Deep mutational scanning
- Nanobody engineering
- Synthetic lethality
- Cancer-related molecular mechanisms
The research combines structural, biochemical, molecular, and cellular approaches to better understand complex biological mechanisms and develop innovative research tools.
📄 How to Apply
Interested candidates should submit the following documents via email:
- Cover Letter
- Curriculum Vitae (CV)
- Contact information for three referees
📧 Application Email: aprakash@southalabama.edu
Applications will be reviewed immediately, and the start date is flexible.
📌 Job Details
Institution: University of South Alabama
Research Institute: Mitchell Cancer Institute
Research Group: Prakash Lab
Position: Postdoctoral Research Fellow
Location: Mobile, Alabama, USA
Research Areas: DNA Repair | Structural Biology | Nanobody Engineering | Molecular Biology | Biophysics
Key Research: BER | MMR | Mitochondrial DNA | Gene–Environment Interactions | Synthetic Lethality
Research Techniques: X-Ray Crystallography | Biophysics | Deep Mutational Scanning | Cell Assays
Qualification: PhD in Biochemistry, Molecular Biology, Structural Biology, Biophysics, or a Related Field
Start Date: Flexible
Application Review: Immediate
Application Documents: Cover Letter | CV | 3 Referees
Application Mode: Email
Application Email: aprakash@southalabama.edu
Category
Postdoctoral Fellowship | Postdoc Jobs | DNA Repair | Structural Biology | Molecular Biology | Biochemistry | Biophysics | Nanobody Engineering | Mitochondrial DNA | Genome Stability | Cancer Research | USA Jobs | Research Jobs | Life Science Jobs
🏷️ Tags
#Postdoc #PostdoctoralFellowship #DNARepair #StructuralBiology #MolecularBiology #Biochemistry #Biophysics #NanobodyEngineering #GenomeStability #MitochondrialDNA #CancerResearch #ResearchJobs
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