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🧬 Postdoctoral Research Associate in Structural Biology, Protein Biochemistry & Natural Product Biosynthesis | University at Buffalo
Institution: University at Buffalo – Jacobs School of Medicine and Biomedical Sciences
Department: Department of Structural Biology
Laboratory: Gulick Lab – Prof. Andrew Gulick
📍 Location: Buffalo, New York, USA
💼 Position Available: Postdoctoral Research Associate
🔬 Research Areas: Structural Biology | Protein Biochemistry | Natural Product Biosynthesis | Enzymology | Protein Engineering | Biocatalysis | Cryo-EM | X-ray Crystallography | Genome Mining
The Gulick Lab in the Department of Structural Biology at the University at Buffalo is seeking a Postdoctoral Research Associate to work on an NIH-funded research project investigating proteins involved in the biosynthesis of bacterial natural products.
The research combines structural biology, biochemical characterization, protein engineering, and biocatalysis to understand proteins and pathways involved in bacterial natural product biosynthesis.
🔬 Research Background
The Gulick Lab investigates proteins involved in the biosynthesis of bacterial natural products, integrating experimental and computational approaches to characterize protein structure, function, and biosynthetic pathways.
The research program includes:
- Structural biology
- Protein biochemistry
- Enzymology
- Protein engineering
- Biocatalysis
- Bacterial natural product biosynthesis
- Genome and pathway mining
- X-ray crystallography
- Cryo-electron microscopy
- Biochemical characterization
🧪 Postdoctoral Research Focus
The successful candidate will contribute to research investigating proteins involved in bacterial biosynthetic pathways.
The research will involve:
- Protein production, purification, and biochemical analysis.
- Development and implementation of biochemical assays.
- Informatic and genome-mining approaches to identify and characterize biosynthetic pathways.
- Investigation of proteins involved in bacterial natural product biosynthesis.
- Protein structure determination using X-ray crystallography and/or cryo-EM.
- Single-particle cryo-EM analysis.
- Protein engineering and characterization.
- Data analysis and interpretation.
- Preparation and dissemination of research findings.
🧬 Protein Biochemistry & Enzymology
The position provides opportunities to investigate protein function through biochemical and enzymatic approaches.
Research activities may include:
- Recombinant protein production.
- Protein purification.
- Protein characterization.
- Enzyme assay development.
- Enzymology.
- LC-MS and HPLC analysis.
- Small-molecule isolation and characterization.
- Biochemical pathway reconstruction.
- Protein engineering.
🔬 Structural Biology
A major component of the research involves determining and analyzing protein structures.
The successful candidate may work with:
- X-ray crystallography
- Cryo-electron microscopy
- Single-particle analysis
- Protein structure determination
- Structural data analysis
- Computational tools for structural biology
- Structure–function analysis
These approaches will be used to understand the molecular mechanisms of proteins involved in bacterial natural product biosynthesis.
🧬 Natural Product Biosynthesis & Genome Mining
The research also focuses on identifying and characterizing bacterial biosynthetic pathways.
The candidate may contribute to:
- Genome mining.
- Identification of biosynthetic gene clusters.
- Characterization of biosynthetic pathways.
- Pathway reconstruction.
- Genetic manipulation.
- Investigation of natural product biosynthesis.
- Small-molecule isolation and characterization.
💼 Anticipated Responsibilities
The selected Postdoctoral Research Associate will be expected to:
- Produce, purify, and analyze proteins.
- Develop and implement biochemical assays.
- Conduct enzymology studies.
- Perform informatic and genome-mining analyses.
- Identify and characterize bacterial biosynthetic pathways.
- Determine protein structures using X-ray crystallography and/or cryo-EM.
- Perform single-particle cryo-EM analysis where applicable.
- Analyze and interpret research data.
- Maintain and organize research projects.
- Contribute to scientific publications.
- Present and disseminate research findings.
- Work independently and collaboratively across multiple projects.
🎯 Minimum Qualifications
Applicants should have:
- A PhD in Biochemistry, Chemistry, or a related field.
- Background in protein biochemistry, enzymology, biophysical analysis, or structural biology.
- Ability to analyze, publish, and present research data.
- Strong organizational and time-management skills.
- Ability to work independently and collaboratively as part of a research team.
- Ability to manage multiple research projects.
⭐ Preferred Qualifications
Experience or interest in the following areas is desirable:
- Natural product biosynthesis.
- Biosynthetic pathway reconstruction.
- Genetic manipulation.
- Small-molecule isolation and characterization.
- Enzymology and biochemical assay development.
- LC-MS and HPLC analysis.
- X-ray crystallographic analysis.
- Protein structure determination.
- Single-particle cryo-electron microscopy.
- Computational tools for protein structure determination and analysis.
Candidates with experience combining protein biochemistry, structural biology, and computational or biochemical approaches are encouraged to apply.
🌟 What You’ll Gain
The successful postdoctoral researcher will have the opportunity to:
- Work on an NIH-funded research project.
- Develop advanced expertise in structural biology.
- Gain experience in protein production and purification.
- Develop skills in enzymology and biochemical assay development.
- Work with X-ray crystallography and/or cryo-EM.
- Explore bacterial natural product biosynthesis.
- Develop experience in genome mining and pathway analysis.
- Work with LC-MS and HPLC-based approaches.
- Apply computational tools for structural analysis.
- Contribute to peer-reviewed publications.
- Work within an interdisciplinary structural biology research environment.
🏛️ Research Environment
The Gulick Lab, within the Department of Structural Biology at the University at Buffalo’s Jacobs School of Medicine and Biomedical Sciences, combines structural, biochemical, computational, and protein-engineering approaches to investigate biological systems.
The postdoctoral researcher will work in a research environment focused on understanding protein structure and function in bacterial natural product biosynthesis.
📅 Application Timeline
Position Type: Postdoctoral Research Associate
Funding: NIH-funded project
Application Deadline: No fixed deadline stated
The formal University at Buffalo Jobs posting will be posted once finalized. Interested candidates are encouraged to contact the laboratory directly in the interim.
📄 How to Apply
Interested candidates should submit their application materials, ideally combined into a single PDF, to Prof. Andrew Gulick.
📧 Application Email
Email: amgulick@buffalo.edu
Applicants should include:
- Cover Letter – Describing current research experience, future professional goals, and how your experience fits with the broad goals of the lab.
- Curriculum Vitae (CV)
- Names of Three References
Letters of support will be requested from selected candidates.
Formal application: Applicants will also be required to apply through the University at Buffalo Jobs site once the official posting is finalized.
📌 Position Details
Institution: University at Buffalo
School: Jacobs School of Medicine and Biomedical Sciences
Department: Department of Structural Biology
Laboratory: Gulick Lab
PI: Prof. Andrew Gulick
Position: Postdoctoral Research Associate
Location: Buffalo, New York, USA
Funding: NIH-funded
Research Areas: Structural Biology | Protein Biochemistry | Natural Product Biosynthesis | Enzymology | Protein Engineering | Biocatalysis
Key Techniques: Protein Production | Protein Purification | Biochemical Assays | Genome Mining | LC-MS | HPLC | X-ray Crystallography | Cryo-EM | Single-Particle Analysis
Qualification: PhD in Biochemistry, Chemistry, or related field
Preferred Experience: Natural Product Biosynthesis | Enzymology | LC-MS/HPLC | X-ray Crystallography | Cryo-EM | Computational Structural Biology
Application Deadline: No fixed deadline stated
Application Mode: Direct Email / University Jobs Portal
Application Email: amgulick@buffalo.edu
Application Format: Ideally a single PDF
Lab Website: buffalo.edu/~amgulick
Category
Postdoctoral Position | Structural Biology | Protein Biochemistry | Natural Product Biosynthesis | Enzymology | Genome Mining | Research Jobs | Postdoc Jobs | USA Jobs | University Jobs
🏷️ Tags
#PostdoctoralPosition #PostdocJobs #UniversityAtBuffalo #GulickLab #StructuralBiology #ProteinBiochemistry #NaturalProductBiosynthesis
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