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🧬 PhD Position in Leukemia TCR Discovery | Charité – Universitätsmedizin Berlin
Institution: Charité – Universitätsmedizin Berlin
Laboratory: Penter Lab
📍 Location: Berlin, Germany
💼 Position Available: PhD Research Position
🔬 Research Area: Acute Myeloid Leukemia (AML) | Immunotherapy | T-Cell Receptors (TCRs) | Single-Cell Immunology | Bioinformatics | Immunogenomics | Hematopoietic Stem Cell Transplantation
The Penter Lab at Charité – Universitätsmedizin Berlin is seeking a highly motivated PhD researcher to join an exciting research project focused on the discovery and characterization of leukemia-specific T-cell receptors (TCRs).
The position offers an opportunity to work at the intersection of cancer immunology, single-cell research, immunogenomics, bioinformatics, and immunotherapy.
The position comes with guaranteed funding for three years through the German José Carreras Leukemia Foundation.
Application Deadline: October 12, 2026
🔬 What You’ll Work On
Leukemia TCR Discovery
The PhD project will utilize advanced single-cell immunomics approaches to identify and characterize leukemia-specific T-cell receptors (TCRs).
The research aims to discover promising TCR candidates that could contribute to the development of future immunotherapeutic strategies for leukemia.
Single-Cell Immunomics
Apply cutting-edge single-cell approaches to investigate immune responses and identify T-cell populations relevant to leukemia.
Research activities will involve the analysis and interpretation of complex single-cell immunological datasets.
Immunogenomics Data Analysis
Analyze large-scale immunogenomics datasets, including data generated through approaches such as:
- Whole-exome sequencing
- Single-cell analysis
- T-cell receptor analysis
- Genomic and immunological profiling
TCR Identification & Characterization
Identify T-cell receptors capable of recognizing leukemia-associated targets.
The project will combine computational analysis with experimental approaches to investigate the functional properties of promising TCR candidates.
Functional Experiments
Conduct or contribute to functional experiments designed to validate and characterize TCRs and their ability to recognize relevant leukemia targets.
Immunotherapy Development
Develop promising T-cell receptor candidates as potential leads for future cancer immunotherapy and leukemia treatment strategies.
Hematopoietic Stem Cell Transplantation
The research project also incorporates aspects of hematopoietic stem cell transplantation, providing an opportunity to investigate immune mechanisms relevant to leukemia treatment.
🎯 Ideal Candidates
The ideal candidate should have a strong interest in bioinformatics, computational biology, immunology, leukemia research, and cancer immunotherapy.
Candidates with relevant experience in the following areas are particularly encouraged to apply:
- Bioinformatics
- R programming
- Python programming
- Command-line computing
- High-performance computing (HPC)
- Web-based analytical approaches
- Dry-lab research
- Computational biology
- Immunogenomics
An interest in the following research areas is highly desirable:
- Blood malignancies
- Leukemia biology
- Cancer immunology
- Immunotherapy
- T-cell biology
The position is particularly suitable for candidates who are enthusiastic about combining wet-lab and computational approaches in an interdisciplinary research environment.
🧪 Research Focus
The PhD project focuses on discovering and characterizing leukemia-specific T-cell receptors and exploring their potential applications in future immunotherapy.
The research integrates:
- Acute Myeloid Leukemia (AML) research
- Cancer immunology
- Single-cell immunomics
- Immunogenomics
- Bioinformatics
- Whole-exome sequencing
- T-cell receptor discovery
- Functional experiments
- Hematopoietic stem cell transplantation
- Immunotherapy development
The selected PhD researcher will contribute to the identification of promising TCR candidates for future leukemia immunotherapies.
💻 Computational & Analytical Skills
Candidates with experience or interest in the following areas are encouraged to apply:
- R
- Python
- Command-line computing
- Linux-based analysis
- High-performance computing
- Bioinformatics workflows
- Immunogenomics data analysis
- Single-cell data analysis
- Genomic data analysis
- Web-based analytical tools
Experience combining computational approaches with experimental research will be advantageous.
🌟 What You’ll Gain
- A fully funded PhD position for three years.
- Opportunity to conduct cutting-edge research in leukemia and cancer immunology.
- Training in single-cell immunomics and immunogenomics.
- Experience analyzing complex genomic and immunological datasets.
- Exposure to advanced bioinformatics and computational biology approaches.
- Opportunity to identify and characterize leukemia-specific T-cell receptors.
- Experience with functional experimental approaches.
- Training at the interface of wet-lab and dry-lab research.
- Opportunity to contribute to the development of future immunotherapy strategies.
- Experience working in an internationally recognized biomedical research environment.
💼 Anticipated Responsibilities
The selected PhD researcher will be expected to:
- Conduct research focused on the discovery of leukemia-specific T-cell receptors.
- Analyze immunogenomics and sequencing datasets.
- Apply single-cell approaches to investigate immune responses.
- Identify potential TCR candidates recognizing leukemia-associated targets.
- Participate in functional experiments for TCR characterization.
- Utilize bioinformatics tools and computational workflows.
- Work with programming languages such as R and Python.
- Use command-line and high-performance computing resources where required.
- Collaborate with researchers across interdisciplinary research areas.
- Interpret research findings and contribute to scientific publications.
- Help develop promising TCR candidates for future immunotherapy applications.
🎓 Position Details
Program: PhD Research Position
Position: PhD Researcher
Institution: Charité – Universitätsmedizin Berlin
Laboratory: Penter Lab
Location: Berlin, Germany
Funding Duration: 3 Years
Funding: German José Carreras Leukemia Foundation
Research Areas: AML | Leukemia | Immunotherapy | T-Cell Receptors | Single-Cell Immunology | Immunogenomics | Bioinformatics
Application Deadline: October 12, 2026
📄 How to Apply
Interested candidates should submit their application to the Penter Lab at Charité – Universitätsmedizin Berlin.
Applicants are requested to include:
- A Letter of Motivation
- A Summary of Research Interests and Experience
- Relevant References
Candidates are encouraged to highlight their experience and interests in areas such as bioinformatics, R, Python, high-performance computing, single-cell analysis, blood malignancies, and immunotherapy.
🌐 Research Group Website: Penter Lab
Application Deadline: October 12, 2026
📌 Job Details
Institution: Charité – Universitätsmedizin Berlin
Laboratory: Penter Lab
Position: PhD Research Position
Location: Berlin, Germany
Funding: Guaranteed for 3 Years
Funding Organization: German José Carreras Leukemia Foundation
Research Areas: Leukemia | AML | TCR Discovery | Immunotherapy | Single-Cell Research | Immunogenomics | Bioinformatics
Computational Skills: R | Python | Command Line | High-Performance Computing | Bioinformatics
Research Approaches: Wet Lab | Dry Lab | Web-Based Analytical Approaches
Application Deadline: October 12, 2026
Category
PhD Position | Cancer Research | Leukemia Research | Immunology | Immunotherapy | Bioinformatics | Single-Cell Research | Genomics | Biomedical Research | Germany Jobs
🏷️ Tags
#PhDPosition #PhD #LeukemiaResearch #AML #Immunotherapy #TCRDiscovery #SingleCell #Bioinformatics #Immunogenomics #CancerResearch #Charité #Berlin #Germany #BiomedicalResearch
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