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🧬 Postdoctoral Position in Organic & Medicinal Chemistry | Université Paris Cité
Institution: Université Paris Cité
Laboratory: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT, UMR CNRS 8601)
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
📍 Location: Paris, France
💼 Position Available: Postdoctoral Researcher
🔬 Research Area: Organic Chemistry | Medicinal Chemistry | β-Lactamase Inhibitors | Antimicrobial Resistance | β-Lactams | Chemical Biology | Drug Discovery
The Team “Chemistry of RNAs, Nucleosides, Peptides and Heterocycles” at the Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT, UMR CNRS 8601), Université Paris Cité, is seeking a motivated Postdoctoral Researcher to contribute to research addressing antimicrobial resistance.
The project focuses on developing new synthetic strategies to expand the chemical diversity of β-lactamase inhibitors and β-lactams, with particular emphasis on enzymes such as Klebsiella pneumoniae carbapenemases (KPC).
The research forms part of a multidisciplinary consortium combining expertise in antimicrobial resistance, β-lactamase evolution, X-ray structural studies, organic synthesis, and computational modelling.
🔬 What You’ll Work On
β-Lactamase Inhibitor Development
Develop and investigate new chemical strategies for identifying β-lactamase inhibitors capable of addressing bacterial resistance mechanisms.
β-Lactam Chemistry
Design and synthesize new β-lactam scaffolds with the goal of expanding chemical diversity and exploring their potential against resistant bacterial enzymes.
KPC Enzyme Research
Study Klebsiella pneumoniae carbapenemases (KPC) and their role in antimicrobial resistance.
Chemical Diversity & Enzyme Evolution
Integrate knowledge of the mutational landscape of KPC enzymes with the development of original chemical scaffolds.
Structure-Guided Research
Work within a consortium combining X-ray structural analysis, organic synthesis, β-lactamase evolution, and computational modelling to investigate enzyme–compound interactions.
Chemistry–Biology Interface
Apply synthetic chemistry approaches to biological questions related to antimicrobial resistance and enzyme evolution.
🎯 Your Role
The selected Postdoctoral Researcher will be expected to:
- Develop synthetic strategies for β-lactamase inhibitors and β-lactams.
- Design and synthesize original chemical scaffolds.
- Investigate compounds targeting β-lactamases, particularly KPC enzymes.
- Contribute to research addressing antimicrobial resistance.
- Integrate experimental information on the mutational landscape of KPC enzymes with chemical synthesis.
- Explore chemical scaffolds designed to exploit evolutionary constraints of β-lactamases.
- Collaborate with researchers specializing in antimicrobial resistance and β-lactamase evolution.
- Work alongside researchers using X-ray structural studies and computational modelling.
- Characterize and evaluate newly developed chemical compounds.
- Contribute to scientific publications and research dissemination.
- Participate in interdisciplinary research at the interface of chemistry and biology.
🧪 Research Focus
The project focuses on the development of chemical approaches to combat antimicrobial resistance, particularly resistance associated with β-lactamase enzymes.
Key areas include:
- Organic Chemistry
- Medicinal Chemistry
- β-Lactam Chemistry
- β-Lactamase Inhibitors
- β-Lactams
- Antimicrobial Resistance
- KPC Enzymes
- Enzyme Evolution
- Chemical Biology
- Drug Discovery
- Synthetic Chemistry
- Structure-Based Research
- Computational Modelling
- X-ray Structural Studies
The project aims to combine chemical synthesis with knowledge of enzyme evolution to identify compounds capable of exploiting evolutionary constraints in β-lactamases.
👨🔬 Ideal Candidates
Applicants should demonstrate:
- Strong knowledge of organic chemistry.
- Strong knowledge of medicinal chemistry.
- A clear interest in research at the interface between chemistry and biology.
- Motivation to work on interdisciplinary research related to antimicrobial resistance.
- Ability to contribute to synthetic chemistry research within a collaborative research environment.
Experience relevant to drug discovery, chemical biology, β-lactam chemistry, or medicinal chemistry would be valuable for the project.
⭐ Preferred Skills & Experience
Relevant expertise may include:
- Organic Chemistry
- Medicinal Chemistry
- Synthetic Organic Chemistry
- Chemical Biology
- β-Lactam Chemistry
- β-Lactamase Inhibitors
- Drug Discovery
- Antimicrobial Resistance
- Enzyme Inhibitor Design
- Molecular Design
- Structure-Based Drug Discovery
- Computational Chemistry
- Enzyme Evolution
- Chemical Synthesis
The position particularly suits candidates interested in applying organic and medicinal chemistry to biological and antimicrobial resistance challenges.
🌟 What You’ll Gain
- Opportunity to work on an important antimicrobial resistance research challenge.
- Experience developing novel β-lactamase inhibitors and β-lactams.
- Exposure to research on KPC enzymes and enzyme evolution.
- Experience working at the interface of organic chemistry and biology.
- Opportunity to collaborate with researchers in organic synthesis, antimicrobial resistance, structural biology, and computational modelling.
- Exposure to multidisciplinary approaches combining chemical synthesis, X-ray studies, and computational modelling.
- Opportunity to contribute to research addressing bacterial resistance mechanisms.
- Experience within an interdisciplinary research team at Université Paris Cité and CNRS.
🏛️ Research Environment
The position is based at the Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT, UMR CNRS 8601) at Université Paris Cité.
The selected researcher will join the Chemistry of RNAs, Nucleosides, Peptides and Heterocycles team and contribute to a multidisciplinary consortium focused on antimicrobial resistance.
The consortium combines expertise in:
- Antimicrobial Resistance
- β-Lactamase Evolution
- X-ray Structural Analysis
- Organic Synthesis
- Computational Modelling
This environment provides an opportunity to work across synthetic chemistry, medicinal chemistry, molecular biology, and antimicrobial research.
💼 Position Details
Position: Postdoctoral Researcher
Institution: Université Paris Cité
Laboratory: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT)
CNRS Unit: UMR CNRS 8601
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
Location: Paris, France
Research Focus: Organic & Medicinal Chemistry
Research Areas: β-Lactamase Inhibitors | β-Lactams | Antimicrobial Resistance | KPC Enzymes | Chemical Biology
Position Duration: 12 months
Expected Start: Between January and March 2027
Research Theme: Development of β-Lactamase Inhibitors and β-Lactams
📄 How to Apply
Interested candidates should contact:
📩 Application Contact
Laura Iannazzo
Institution: Université Paris Cité, LCBPT – UMR CNRS 8601
Research Team: Chemistry of RNA, Nucleosides, Peptides and Heterocycles
Email: laura.iannazzo@u-paris.fr
Candidates should contact the research team with their CV and relevant application information.
📅 Key Dates
Application Status: Open
Application Deadline: No fixed deadline stated
Recommended: Apply as soon as possible
Position Duration: 12 months
Expected Start: January–March 2027
Location: Paris, France
📌 Job Details
Institution: Université Paris Cité
Laboratory: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT)
CNRS Unit: UMR CNRS 8601
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
Position: Postdoctoral Researcher
Location: Paris, France
Research Area: Organic & Medicinal Chemistry
Research Areas: β-Lactamase Inhibitors | β-Lactams | Antimicrobial Resistance | KPC | Chemical Biology | Drug Discovery
Key Topics: β-Lactamase Evolution | Organic Synthesis | Enzyme Inhibition | X-ray Structural Studies | Computational Modelling
Position Duration: 12 months
Expected Start: January–March 2027
Application Mode: Email
Contact: Laura Iannazzo
Application Email: laura.iannazzo@u-paris.fr
Application Deadline: No fixed deadline stated
Application Recommendation: Apply as soon as possible
Category
Postdoctoral Position | Postdoc | Organic Chemistry | Medicinal Chemistry | β-Lactamase Inhibitors | β-Lactams | Antimicrobial Resistance | Chemical Biology | Drug Discovery | CNRS | Université Paris Cité | France
🏷️ Tags
#Postdoc #PostdoctoralPosition #OrganicChemistry #MedicinalChemistry #AntimicrobialResistance #BetaLactamase #DrugDiscovery #ChemicalBiology #OrganicSynthesis
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