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🧬 PhD & Postdoctoral Positions – Vascular Control of NASH Progression | InversoLab, Milan
Institution: San Raffaele Scientific Institute – Unit of Vascular Pathobiology
Research Group: InversoLab
📍 Location: Milan, Italy 🇮🇹
💼 Positions Available: PhD Positions & 2 Postdoctoral Positions
🔬 Research Area: Liver Pathobiology | Vascular Biology | Immunology | NASH | Liver Disease | Endothelial Biology | Immunometabolism | Spatial Biology
InversoLab at the San Raffaele Scientific Institute, Milan, is inviting applications for PhD and Postdoctoral positions within the ERC Consolidator Grant project CONNASHION (2025–2029).
The research project, “Vascular Control of NASH Progression (CONNASHION),” investigates how the liver vasculature controls the progression of non-alcoholic steatohepatitis (NASH) and how vascular dynamics interact with immune and metabolic processes during liver disease progression.
🔬 Project Title
Vascular Control of NASH Progression (CONNASHION)
The project focuses on understanding how vascular zonation and endothelial–immune interactions influence the progression of NASH.
NASH is a complex liver disease associated with metabolic dysfunction, inflammation, fibrosis, and potentially cirrhosis. The project aims to investigate how changes in the liver vascular environment and lobular architecture contribute to disease progression.
The research will integrate murine models of diet-induced NASH with human samples, advanced imaging, and spatial multi-omics approaches.
🔬 What You’ll Work On
🫀 Liver Vascular Biology
Investigate the role of the liver vasculature in regulating liver homeostasis and disease progression.
🧬 Liver Lobule Zonation
Study the spatial organization and vascular zonation of the liver lobule and how this organization changes during NASH progression.
🧪 NASH & Liver Pathobiology
Investigate the mechanisms underlying non-alcoholic steatohepatitis, including changes in vascular architecture, inflammation, and tissue organization.
🔬 Endothelial–Immune Crosstalk
Study communication between endothelial cells and immune cells and its contribution to liver disease progression.
🐭 Murine NASH Models
Use diet-induced NASH mouse models to investigate vascular and pathological changes associated with different stages of disease.
🧫 Human Samples
Analyze human liver samples to investigate the relevance of findings obtained from experimental models.
🔬 Advanced Imaging
Apply advanced imaging approaches to characterize vascular structures, cellular interactions, and spatial changes within diseased liver tissue.
🧬 Spatial Multi-Omics
Use spatial multi-omics technologies to investigate molecular and cellular changes while preserving their spatial context within the liver.
📊 Disease Progression Analysis
Correlate vascular dynamics and spatial molecular patterns with different stages of NASH progression to identify mechanisms and potential diagnostic or therapeutic opportunities.
🎯 Research Focus
The CONNASHION project integrates:
- Liver pathobiology
- Vascular biology
- Immunology
- NASH progression
- Liver lobule zonation
- Endothelial biology
- Endothelial–immune interactions
- Murine disease models
- Human liver samples
- Advanced imaging
- Spatial biology
- Spatial multi-omics
- Disease-stage characterization
The overarching objective is to determine how vascular zonation and vascular–immune interactions influence NASH progression and whether these mechanisms can provide new insights into disease diagnosis and treatment.
👩🔬 Ideal Candidates
Applicants should have a strong interest in liver pathobiology, vascular biology, immunology, or related research areas.
🎓 For PhD Applicants
Candidates with an appropriate academic background in areas such as:
- Biological Sciences
- Biotechnology
- Molecular Biology
- Biomedical Sciences
- Biochemistry
- Immunology
- Vascular Biology
- Liver Biology
- Related life-science disciplines
are encouraged to apply.
🔬 For Postdoctoral Applicants
Applicants should have relevant research experience in areas related to:
- Liver pathobiology
- Vascular biology
- Immunology
- Disease biology
- Cellular and molecular biology
- In vivo experimental research
⭐ Desirable Experience
The following experience is highly desirable but not mandatory:
- Liver pathobiology
- Vascular biology
- Immunology
- In vivo experimentation
- Murine models
Applicants with interdisciplinary research experience are encouraged to apply.
🌟 What You’ll Gain
- Opportunity to work on an ERC-funded research project.
- Training in advanced liver and vascular biology.
- Exposure to NASH and metabolic liver disease research.
- Experience with murine models of diet-induced NASH.
- Exposure to human liver samples and clinically relevant research.
- Training in advanced imaging technologies.
- Experience with spatial biology and spatial multi-omics.
- Opportunity to study endothelial–immune interactions.
- Interdisciplinary research experience combining vascular biology, immunology, and liver pathobiology.
- Collaboration with researchers and clinicians at San Raffaele Scientific Institute.
- Access to the scientific environment of a large biomedical research institution.
- Opportunities for scientific training, collaboration, presentations, and research publications.
🏥 Research Environment
The San Raffaele Scientific Institute provides an interdisciplinary research environment with:
- 1,000+ researchers
- 100+ research groups
- 4 technology centres
- Dedicated research infrastructure
- Collaboration with the Liver Center
- Collaboration with Ospedale San Raffaele
- Access to clinical research and patient-derived samples
- Graduate courses through Vita-Salute San Raffaele University (UniSR)
The positions are part of the ERC Consolidator Grant CONNASHION project, funded for the 2025–2029 period.
💰 Funding & Duration
Funding: ERC Consolidator Grant – CONNASHION
Project Period: 2025–2029
Position Duration: 4 Years
Positions: PhD Positions + 2 Postdoctoral Positions
Research Environment: San Raffaele Scientific Institute, Milan
💼 Position Details
Positions: PhD & Postdoctoral Researchers
Institution: San Raffaele Scientific Institute
Research Group: InversoLab – Unit of Vascular Pathobiology
Location: Milan, Italy 🇮🇹
Project: CONNASHION – Vascular Control of NASH Progression
Funding: ERC Consolidator Grant
Project Duration: 2025–2029
Position Duration: 4 Years
Postdoctoral Openings: 2
Core Research Areas: Liver Pathobiology | Vascular Biology | Immunology
Additional Areas: NASH | Liver Lobule Zonation | Endothelial–Immune Crosstalk | Spatial Biology
🧪 Key Technical & Research Skills
The research involves experience or interest in:
- Liver pathobiology
- Vascular biology
- Immunology
- NASH research
- Liver disease models
- Endothelial biology
- Liver lobule zonation
- Endothelial–immune crosstalk
- In vivo experimentation
- Murine models
- Diet-induced NASH models
- Human tissue samples
- Advanced imaging
- Spatial biology
- Spatial multi-omics
- Molecular biology
- Cellular biology
- Disease progression analysis
- Translational research
📄 How to Apply
Interested candidates should visit the InversoLab website and submit their application materials.
Applicants should provide:
- Curriculum Vitae (CV)
- Motivation Letter
- Contact information for two references
📩 Email: info@inversolab.org
🌐 Website: www.inversolab.org
Applicants should highlight their relevant background in liver pathobiology, vascular biology, immunology, and/or in vivo research.
📌 Job Details
Institution: San Raffaele Scientific Institute
Unit: Unit of Vascular Pathobiology
Research Group: InversoLab
Positions: PhD Positions | 2 Postdoctoral Positions
Project: Vascular Control of NASH Progression (CONNASHION)
Location: Milan, Italy 🇮🇹
Funding: ERC Consolidator Grant
Funding Period: 2025–2029
Duration: 4 Years
Core Research: Liver Pathobiology | Vascular Biology | Immunology
Research Areas: NASH | Liver Lobule Zonation | Endothelial–Immune Crosstalk | Murine Models | Human Samples | Spatial Multi-Omics
Desirable Background: Liver Pathobiology | Vascular Biology | Immunology
Desirable Experience: In Vivo Experimentation | Murine Models
Application Mode: Email
Application Email: info@inversolab.org
Required Documents: CV | Motivation Letter | Contact Information for 2 References
Category
PhD Positions | Postdoctoral Positions | Liver Research | NASH Research | Vascular Biology Jobs | Immunology Jobs | Liver Pathobiology | Biomedical Research | Molecular Biology | In Vivo Research | Spatial Biology | Multi-Omics | San Raffaele Scientific Institute | Milan Research Jobs | Italy PhD | Italy Postdoc
🏷️ Tags
#PhD #Postdoc #PostdoctoralPosition #SanRaffaele #InversoLab #Milan #Italy #NASH #LiverResearch #LiverPathobiology #VascularBiology #Immunology
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