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🧬 Postdoctoral Researcher – Tumor Mechanobiology, Quantitative Imaging & Colorectal Cancer | Institut Gustave Roussy
Institution: Institut Gustave Roussy – Tumor Dynamics and Plasticity Group
📍 Location: Villejuif, Paris, France
💼 Position Available: Postdoctoral Researcher
🔬 Research Area: Tumor Mechanobiology | Colorectal Cancer | Cancer Biology | Quantitative Biology | Image Analysis | Spatial Transcriptomics | Single-Cell Sequencing | Tumor Plasticity
The Tumor Dynamics and Plasticity Group, led by Carlos Pérez-González and supported by an ERC Starting Grant, is seeking a highly motivated Postdoctoral Researcher to investigate how mechanochemical signals drive tumor cell state patterning, tumor progression, and clinical outcomes in colorectal cancer.
The project combines tissue mechanics, quantitative imaging, and transcriptomics to understand how physical and molecular cues shape tumor behavior and cellular plasticity.
🔬 What You’ll Work On
Tumor Mechanobiology
Investigate how mechanochemical and tissue-level signals influence tumor cell behavior, cellular state transitions, tumor progression, and disease outcomes.
Colorectal Cancer
Study the mechanical evolution of colorectal cancer and how changes in the tumor microenvironment contribute to cancer progression and cellular heterogeneity.
Quantitative Image Analysis
Develop and apply computational approaches for analyzing biological images, including:
- Cell segmentation
- Cell tracking
- Cell morphometry
- Quantitative imaging
- Analysis of cellular and tissue-level phenotypes
Spatial Transcriptomics
Integrate spatial transcriptomic approaches with imaging and tissue mechanics to investigate the spatial organization of tumor cell states and molecular programs.
Single-Cell Sequencing
Use single-cell sequencing approaches to characterize tumor heterogeneity and identify distinct cellular states associated with tumor progression.
Tissue Mechanics & Transcriptomics
Bridge tissue mechanics with transcriptomic information to understand how physical forces and molecular processes interact during colorectal cancer evolution.
🧪 Research Approaches
The successful candidate will work across computational and experimental approaches, including:
- Image analysis
- Cell segmentation
- Cell tracking
- Cell morphometry
- Quantitative biology
- Spatial transcriptomics
- Single-cell sequencing
- Tissue mechanics
- Transcriptomic analysis
- Computational modeling and data analysis
The project provides an opportunity to connect quantitative imaging with molecular profiling to study tumor dynamics and plasticity.
🧫 Experimental & Translational Opportunities
The research environment provides access to patient-derived organoids and clinical samples, creating opportunities to connect quantitative and computational findings with biologically relevant colorectal cancer models.
The successful researcher will work in an interdisciplinary environment combining computational/quantitative biology with wet-lab and translational cancer research.
🎯 Ideal Candidates
Applicants should have expertise or strong interest in:
- Computational Biology
- Quantitative Biology
- Bioinformatics
- Image Analysis
- Cancer Biology
- Biophysics
- Computational Modeling
- Related quantitative life-science disciplines
Experience with the following will be particularly relevant:
- Image analysis
- Cell segmentation
- Cell tracking
- Morphometric analysis
- Spatial transcriptomics
- Single-cell sequencing
- Quantitative data analysis
The position is particularly suited to candidates interested in working across dry-lab and wet-lab research. Wet-lab experience is considered an advantage but is not required.
🌟 What You’ll Gain
- Opportunity to study mechanical evolution of colorectal cancer.
- Experience at the intersection of mechanobiology and cancer biology.
- Advanced exposure to quantitative image analysis.
- Hands-on experience with cell segmentation, tracking, and morphometry.
- Exposure to spatial transcriptomics and single-cell sequencing.
- Opportunity to work with patient-derived organoids and clinical samples.
- Experience integrating tissue mechanics and molecular data.
- Opportunity to work within a multidisciplinary cancer research environment.
- Collaboration with researchers studying tumor dynamics, plasticity, and cancer progression.
🏥 Research Environment
The Tumor Dynamics and Plasticity Group focuses on understanding how tumor cells dynamically respond to their physical and molecular environment.
The group brings together mechanobiology, quantitative imaging, transcriptomics, and computational approaches to investigate tumor evolution and cellular plasticity.
The position also provides access to patient-derived organoids and clinical samples through the research environment at Institut Gustave Roussy, enabling connections between experimental models and clinically relevant cancer biology.
💼 Position Details
Position: Postdoctoral Researcher
Institution: Institut Gustave Roussy
Research Group: Tumor Dynamics and Plasticity Group
Group Leader: Carlos Pérez-González
Funding: ERC Starting Grant
Location: Villejuif, Paris, France
Duration: 2 Years, Extendable
Research Focus: Tumor Mechanobiology | Colorectal Cancer | Tumor Plasticity
Key Areas: Quantitative Biology | Image Analysis | Tissue Mechanics | Transcriptomics
Advanced Approaches: Spatial Transcriptomics | Single-Cell Sequencing | Quantitative Imaging
Wet-Lab Experience: Advantage, but Not Required
🧬 Research Focus
The project focuses on the mechanical evolution of colorectal cancer, investigating how tumor-associated mechanical and biochemical signals contribute to cellular state patterning, progression, and clinical outcomes.
The broader research areas include:
- Tumor mechanobiology
- Tissue mechanics
- Tumor cell plasticity
- Colorectal cancer
- Quantitative imaging
- Image analysis
- Cell segmentation
- Cell tracking
- Cell morphometry
- Spatial transcriptomics
- Single-cell sequencing
- Computational biology
- Tumor progression
- Patient-derived organoids
- Clinical cancer samples
📄 How to Apply
Interested candidates should submit:
- Motivation Letter
- Curriculum Vitae (CV)
- Contact details for references who can provide recommendations
📧 Application Email: carlos.perezgonzalez@gustaveroussy.fr
Application Deadline: November 15
Applications should demonstrate relevant experience in computational/quantitative biology, image analysis, transcriptomics, or related research areas.
📌 Job Details
Institution: Institut Gustave Roussy
Research Group: Tumor Dynamics and Plasticity
Group Leader: Carlos Pérez-González
Position: Postdoctoral Researcher
Location: Villejuif, Paris, France
Funding: ERC Starting Grant
Contract Duration: 2 Years, Extendable
Research Area: Colorectal Cancer | Tumor Mechanobiology | Tumor Plasticity
Additional Research Areas: Tissue Mechanics | Quantitative Biology | Cancer Biology | Transcriptomics
Key Technologies: Image Analysis | Cell Segmentation | Cell Tracking | Morphometry | Spatial Transcriptomics | Single-Cell Sequencing
Experimental Resources: Patient-Derived Organoids | Clinical Samples
Candidate Profile: Computational Biology | Quantitative Biology | Related Fields
Wet-Lab Experience: Preferred but Not Required
Application Mode: Email
Application Materials: Motivation Letter | CV | Reference Contacts
Application Email: carlos.perezgonzalez@gustaveroussy.fr
Application Deadline: November 15
Category
Postdoctoral Position | Postdoc France | Cancer Research | Colorectal Cancer | Tumor Mechanobiology | Quantitative Biology | Computational Biology | Bioinformatics | Image Analysis | Spatial Transcriptomics | Single-Cell Sequencing | Cancer Biology | Biophysics | Tumor Plasticity | Paris Research Jobs
🏷️ Tags
#Postdoc #PostdoctoralPosition #PostdocFrance #GustaveRoussy #CancerResearch #ColorectalCancer #TumorMechanobiology #CancerBiology #QuantitativeBiology #ComputationalBiology #Bioinformatics
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