WhatsApp Channel
Telegram Group
🧬 PhD Position – Mitochondrial Dysfunction, Cancer Metabolism & Metastasis | CBM-CSIC/UAM
Institution: Centro de Biología Molecular Severo Ochoa (CBM-CSIC/UAM)
Laboratory: Balsa Lab
📍 Location: Madrid, Spain 🇪🇸
💼 Position: PhD Researcher
🔬 Research Areas: Cancer Metabolism | Mitochondrial Dysfunction | Metastasis | Cell Biology | Metabolomics | Proteomics | Precision Medicine
The Balsa Lab at the Centro de Biología Molecular Severo Ochoa (CBM-CSIC/UAM) is seeking a motivated PhD candidate for a research project titled “Mitochondrial Dysfunction in Metabolic Diseases.”
The PhD project will investigate how cellular metabolism influences the ability of cancer cells to form metastases in specific organs and explore potential therapeutic vulnerabilities associated with these metabolic adaptations.
🔬 What You’ll Work On
Cancer Metabolism & Metastasis
Investigate how metabolic processes determine the ability of cancer cells to establish metastases in specific organs.
The project will explore the metabolic compatibility required for cancer cells to survive and grow in different tissues, including:
- Liver
- Lung
- Brain
Mitochondrial Dysfunction
Study the role of mitochondrial dysfunction and cellular metabolism in cancer progression and metastatic disease.
The research aims to identify important molecular and metabolic mechanisms that may contribute to organ-specific metastasis.
Therapeutic Vulnerabilities
Investigate whether organ-specific metabolic vulnerabilities can be exploited for potential therapeutic applications.
The project will combine fundamental cancer biology with advanced approaches to identify new opportunities for targeting metastatic cancer cells.
🧪 Advanced Research Approaches
The successful candidate will receive interdisciplinary training in modern experimental approaches, including:
- CRISPR/Cas9 gene editing
- Single-cell RNA sequencing (scRNA-seq)
- Metabolomics
- Proteomics
- Stable isotope tracing
- Cell culture
- Molecular and cellular biology techniques
The research environment provides opportunities to combine multi-omics approaches and advanced experimental models to address important questions in cancer metabolism.
🧬 Research Focus
The PhD project will focus on understanding:
- How metabolism influences cancer metastasis.
- Why cancer cells establish metastases in specific organs.
- Metabolic adaptations within different tissue environments.
- The role of mitochondrial dysfunction in disease.
- Molecular mechanisms underlying metastatic progression.
- Potential metabolic vulnerabilities for therapeutic intervention.
🎯 Ideal Candidates
Applicants should hold a relevant academic background in:
- Biology
- Biotechnology
- Medicine
- Pharmacy
- Or a closely related discipline
Candidates should have:
- A Bachelor’s degree in a relevant scientific discipline.
- A Master’s degree, preferably in Biomedical Sciences or a related field.
- A strong academic record, with a minimum average grade of 8.0.
- A strong interest in cancer biology, metabolism, and biomedical research.
- The motivation to work in a dynamic and collaborative scientific environment.
⭐ Desirable Experience
Previous experience in the following areas will be considered an advantage:
- Cellular techniques
- Molecular biology
- Animal experimentation
- Cell culture
- Biomedical research
Experience in animal experimentation involving Functions A, B and C is particularly valued.
🌟 What You’ll Gain
- Interdisciplinary training in a collaborative scientific environment.
- Experience with state-of-the-art research methodologies.
- Training in CRISPR/Cas9 and gene-editing technologies.
- Hands-on exposure to single-cell RNA sequencing.
- Experience in metabolomics and proteomics.
- Training in stable isotope tracing approaches.
- Research experience in cancer metabolism and metastasis.
- Opportunity to investigate therapeutic vulnerabilities in cancer.
- Development of advanced experimental and analytical skills.
💼 Position Details
Position: PhD Researcher
Institution: Centro de Biología Molecular Severo Ochoa (CBM-CSIC/UAM)
Laboratory: Balsa Lab
Location: Madrid, Spain 🇪🇸
PhD Project: Mitochondrial Dysfunction in Metabolic Diseases
Research Focus: Cancer Metabolism | Organ-Specific Metastasis | Mitochondrial Dysfunction
Target Organs: Liver | Lung | Brain
Research Approaches: CRISPR/Cas9 | scRNA-seq | Metabolomics | Proteomics | Stable Isotope Tracing
📄 How to Apply
Interested candidates should submit the following documents:
- Curriculum Vitae (CV)
- Academic Transcript
Applications should be sent via email to:
📧 Email: ebalsa@cbm.csic.es
📅 Application Deadline
Deadline: 30 October 2026
Applicants are encouraged to submit their applications before the deadline.
📌 Job Details
Institution: Centro de Biología Molecular Severo Ochoa (CBM-CSIC/UAM)
Laboratory: Balsa Lab
Position: PhD Researcher
Location: Madrid, Spain 🇪🇸
Research Areas: Cancer Metabolism | Mitochondrial Dysfunction | Metastasis | Cell Biology
Project: Mitochondrial Dysfunction in Metabolic Diseases
Research Focus: Organ-Specific Cancer Metastasis and Therapeutic Vulnerabilities
Target Tissues: Liver | Lung | Brain
Key Techniques: CRISPR/Cas9 | Single-Cell RNA Sequencing | Metabolomics | Proteomics | Isotope Tracing
Qualification: Bachelor’s Degree in Biology, Biotechnology, Medicine, Pharmacy, or a Related Field
Preferred Education: Master’s Degree in Biomedical Sciences or a Related Discipline
Minimum Academic Grade: 8.0
Desirable Experience: Cell Culture | Molecular Techniques | Animal Experimentation
Application Documents: CV | Academic Transcript
Application Mode: Email
Application Email: ebalsa@cbm.csic.es
Application Deadline: 30 October 2026
Category
PhD Position | Cancer Biology | Cancer Metabolism | Mitochondrial Dysfunction | Metastasis Research | Cell Biology | Metabolomics | Proteomics | CRISPR | Single-Cell RNA Sequencing | Biomedical Research | Spain PhD | Research Jobs
🏷️ Tags
#PhDPosition #CancerMetabolism #CancerBiology #Mitochondria #Metastasis #CRISPR #SingleCellRNAseq #Metabolomics #Proteomics #BiomedicalResearch #CSIC #UAM
Follow Biopractify for more & Join our community : https://chat.whatsapp.com/F38FNCU0nfvFCDf1mYJDbm
About The Author
