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🧬 PhD Position in Organic Synthesis/Glycochemistry – SILYSUGAR | Université de Poitiers
Institution: Université de Poitiers / CNRS 🇫🇷
Research Institute: IC2MP – Institut de Chimie des Milieux et des Matériaux de Poitiers
Research Group: Glycochemistry Group – Organic Synthesis
Project: SILYSUGAR – Harnessing the Ambiphilicity of Silyl Nitronates to Boost Aglycon Structural Diversity in Glycomimetics
📍 Location: Poitiers, France 🇫🇷
💼 Position: PhD Researcher
🔬 Research Areas: Organic Chemistry | Glycochemistry | Glycomimetics | Organic Synthesis | Medicinal Chemistry | Chemistry-Biology Interface
The IC2MP at Université de Poitiers, in collaboration with the CNRS, is offering a PhD position in Organic Synthesis/Glycochemistry as part of the SILYSUGAR (ANR) project.
The project focuses on developing new synthetic strategies for C1-functionalized iminosugar glycomimetics by exploiting the ambiphilicity of silyl nitronates. The research aims to expand the structural diversity of glycomimetics and investigate their potential biological properties.
🔬 Research Project
The successful candidate will work on the development of innovative synthetic approaches for C1-functionalized iminosugars and their biological evaluation.
The research will involve:
- Development of multi-step organic synthesis strategies.
- Synthesis of nitromethyl iminosugars.
- Functionalization of iminosugar scaffolds.
- Exploitation of the ambiphilicity of silyl nitronates.
- Structural and conformational analysis of synthesized molecules.
- Evaluation of glycosidase inhibition in collaboration with project partners.
- Investigation of structure–activity relationships at the chemistry-biology interface.
The project combines synthetic organic chemistry, glycochemistry, conformational analysis, and biological evaluation.
🧪 What You’ll Work On
1️⃣ Organic Synthesis
The PhD researcher will develop and optimize multi-step synthetic routes toward novel iminosugar glycomimetics.
Key activities will include:
- Reaction design and optimization.
- Multi-step synthesis.
- Synthesis and modification of carbohydrate-derived molecules.
- Handling and optimization of synthetic intermediates.
2️⃣ Purification & Characterization
The candidate will be responsible for purification and characterization of synthesized compounds using techniques such as:
- Silica-gel chromatography.
- HPLC purification.
- NMR spectroscopy.
- Mass spectrometry (MS).
- Infrared spectroscopy (IR).
- Other standard organic chemistry characterization techniques.
3️⃣ Conformational Analysis
The project will investigate the conformational properties of synthesized glycomimetics to understand how molecular structure influences their biological properties.
4️⃣ Glycosidase Inhibition
Selected compounds will be evaluated for their ability to interact with and inhibit glycosidase enzymes, in collaboration with research partners.
5️⃣ Chemistry–Biology Interface
The research will connect synthetic chemistry with biological evaluation to investigate the potential of newly developed iminosugar glycomimetics.
🎯 Ideal Candidates
Applicants should have a strong academic background in organic chemistry and practical laboratory experience.
Candidates should possess:
- A solid background in organic chemistry.
- Experience with multi-step organic synthesis.
- Practical experience obtained during an M1/M2 internship or equivalent research project.
- Experience with purification of organic compounds.
- Experience with silica-gel chromatography and/or HPLC.
- Experience with characterization techniques such as NMR, MS, and IR.
- Strong motivation for research in synthetic chemistry.
- Interest in the chemistry-biology interface.
- Ability to work independently and as part of a collaborative research team.
⭐ Skills & Experience
Essential Skills
- Organic synthesis.
- Multi-step synthesis.
- Purification of organic compounds.
- Silica chromatography.
- Spectroscopic characterization.
- NMR spectroscopy.
- Mass spectrometry.
- IR spectroscopy.
Desirable Skills
- Experience in glycochemistry.
- Knowledge of iminosugars or glycomimetics.
- Experience with conformational analysis.
- Interest or experience in medicinal chemistry.
- Familiarity with enzyme inhibition studies.
Note: Previous glycochemistry experience is an advantage but not mandatory.
🌟 What You’ll Gain
- Advanced training in modern organic synthesis.
- Hands-on experience in glycochemistry and glycomimetics.
- Experience developing multi-step synthetic pathways.
- Training in purification and advanced molecular characterization.
- Exposure to conformational analysis.
- Experience investigating glycosidase inhibition.
- Opportunity to work at the interface of chemistry and biology.
- Collaboration with academic research partners.
- Experience within an interdisciplinary international research environment.
💼 Position Details
Position: PhD Researcher
Project: SILYSUGAR – Harnessing the Ambiphilicity of Silyl Nitronates to Boost Aglycon Structural Diversity in Glycomimetics
Funding: ANR
Institution: Université de Poitiers / CNRS
Research Institute: IC2MP – Institut de Chimie des Milieux et des Matériaux de Poitiers
Research Group: Glycochemistry Group
Location: Poitiers, France 🇫🇷
Research Focus: Organic Synthesis | Glycochemistry | Glycomimetics
Key Topics: Iminosugars | Silyl Nitronates | Nitromethyl Iminosugars | Glycosidase Inhibition | Conformational Analysis
📄 Candidate Requirements
Academic Background: Strong background in Organic Chemistry
Experience: M1/M2 internship or equivalent practical research experience
Required Skills: Multi-Step Synthesis | Purification | Silica Chromatography | HPLC | NMR | MS | IR
Preferred Knowledge: Glycochemistry | Glycomimetics | Conformational Analysis
Personal Qualities: Motivation | Teamwork | Research Interest | Chemistry-Biology Interface
Glycochemistry Experience: Advantage, but not mandatory
📩 How to Apply
Interested candidates should submit their application through the CNRS employment portal.
Application Platform: emploi.cnrs.fr
Job Reference: UMR7285-CARNOE-078
Applicants should prepare:
- CV
- Cover Letter
- Contact Details of Two Academic Referees
📧 Scientific Contacts
Yves Blériot: yves.bleriot@univ-poitiers.fr
Nicolas Auberger: nicolas.auberger@univ-poitiers.fr
📅 Application Deadline
Deadline: No specific deadline stated in the advertisement.
Candidates are encouraged to check the CNRS employment portal for the current application status and submission details.
📌 Job Details
Institution: Université de Poitiers / CNRS
Research Institute: IC2MP
Research Group: Glycochemistry Group
Position: PhD Researcher
Project: SILYSUGAR
Location: Poitiers, France 🇫🇷
Funding: ANR
Research Area: Organic Synthesis | Glycochemistry | Glycomimetics
Research Topics: Silyl Nitronates | Iminosugars | Nitromethyl Iminosugars | Conformational Analysis | Glycosidase Inhibition
Required Background: Organic Chemistry
Required Experience: Multi-Step Synthesis | Purification | Characterization
Key Techniques: Silica Chromatography | HPLC | NMR | MS | IR
Desirable: Glycochemistry Experience
Application Documents: CV | Cover Letter | Two Academic Referees
Application Portal: emploi.cnrs.fr
Job Reference: UMR7285-CARNOE-078
Scientific Contacts: yves.bleriot@univ-poitiers.fr | nicolas.auberger@univ-poitiers.fr
Application Deadline: Not Stated
Category
PhD Positions | PhD Jobs | Organic Chemistry Jobs | Glycochemistry Jobs | Organic Synthesis | Glycomimetics | Medicinal Chemistry | CNRS Jobs | Université de Poitiers | France Jobs | Research Jobs
🏷️ Tags
#PhDPosition #PhDJobs #OrganicChemistry #OrganicSynthesis #Glycochemistry #Glycomimetics #MedicinalChemistry #Iminosugars #ChemistryBiology
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