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🧬 Postdoctoral Position in Genome Instability & Chromosome Biology | University of South Florida
Institution: University of South Florida (USF)
Department: Department of Molecular Biosciences
Laboratory: Schmidt Laboratory – Chromosome Instability Group
Principal Investigator: Dr. Kristina Schmidt
📍 Location: Florida, USA
💼 Position Available: NIH-Funded Postdoctoral Researcher
🔬 Research Area: Genome Stability | Chromosome Instability | Bloom Syndrome | DNA Replication | DNA Repair | Cancer Biology | Molecular & Cell Biology
The Schmidt Laboratory (Chromosome Instability Group) in the Department of Molecular Biosciences at the University of South Florida (USF) is seeking a motivated Postdoctoral Researcher to join an NIH-funded research program investigating the molecular mechanisms that maintain genome stability.
The research focuses on Bloom syndrome, a rare chromosome instability disorder characterized by exceptionally high cancer susceptibility. The project aims to understand how the BLM helicase and its interacting proteins protect the genome during DNA replication and repair, how loss of BLM causes chromosome instability, and how Bloom syndrome-specific cellular vulnerabilities may be exploited for potential therapeutic approaches.
The successful candidate will have the opportunity to develop an independent research project within this broad research framework.
🔬 What You’ll Work On
🧬 Chromosome Instability
Investigate the molecular mechanisms responsible for chromosome instability and understand how defects in genome maintenance pathways contribute to disease.
🧬 BLM Helicase Function
Study the function and regulation of the BLM helicase, an important component of genome maintenance, and its interactions with other proteins.
🧪 DNA Replication & Fork Stability
Investigate DNA replication stress, replication fork stability, and mechanisms that protect the genome during DNA replication.
🔬 DNA Repair & Homologous Recombination
Study mechanisms involved in DNA repair and homologous recombination, particularly in the context of Bloom syndrome.
🧬 R-Loops & G-Quadruplexes
Explore the roles of R-loops and G-quadruplex structures in genome instability and DNA replication.
🎯 Therapeutic Vulnerabilities
Identify Bloom syndrome-specific cellular vulnerabilities and potential therapeutic targets that could provide new approaches to treating genome instability-associated disease.
🎯 Your Role
The selected Postdoctoral Researcher will be expected to:
- Investigate molecular mechanisms underlying genome instability.
- Study BLM helicase function, regulation, and interacting proteins.
- Examine DNA replication stress and replication fork stability.
- Investigate DNA repair and homologous recombination pathways.
- Study the role of R-loops and G-quadruplexes in genome maintenance.
- Analyze protein-protein interactions involved in genome stability pathways.
- Work with human cell-based models of Bloom syndrome.
- Develop and pursue an independent research project within the laboratory’s research framework.
- Apply molecular and cell biological approaches to understand chromosome instability.
- Develop expertise in next-generation sequencing, proteomics, and single-molecule approaches.
- Identify potential cellular vulnerabilities and therapeutic targets.
- Contribute to scientific publications and research dissemination.
- Collaborate effectively with other researchers while maintaining independent research activities.
🧪 Research Focus
The research program investigates how cells protect their genomes from instability, with a particular focus on Bloom syndrome and the BLM helicase.
Key research areas include:
- Chromosome Instability
- Genome Stability
- Bloom Syndrome
- BLM Helicase
- DNA Replication
- Replication Stress
- Replication Fork Stability
- DNA Repair
- Homologous Recombination
- R-Loops
- G-Quadruplexes
- Protein-Protein Interactions
- Genome Maintenance
- Cancer Biology
- Therapeutic Target Identification
- Next-Generation Sequencing
- Proteomics
- Single-Molecule Biology
The overall goal is to understand how defects in genome maintenance pathways produce chromosome instability and cancer susceptibility, while identifying potential therapeutic opportunities.
👨🔬 Ideal Candidates
Applicants should have:
- A PhD in Molecular Biology, Cell Biology, Genetics, Biochemistry, Cancer Biology, or a related field.
- A strong interest in DNA replication, DNA repair, chromosome biology, or genome instability.
- Experience with molecular biology, cell biology, or next-generation sequencing techniques.
- A demonstrated record of productive research.
- Strong scientific communication skills.
- The ability to work independently and collaboratively.
- Motivation to investigate fundamental mechanisms of genome stability and disease.
⭐ Preferred Skills & Experience
Relevant experience may include:
- Molecular Biology
- Cell Biology
- Genetics
- Biochemistry
- Cancer Biology
- DNA Replication
- DNA Repair
- Homologous Recombination
- Genome Instability
- Chromosome Biology
- Next-Generation Sequencing
- Proteomics
- Single-Molecule Techniques
- Protein-Protein Interaction Studies
- DNA Replication Stress
- Replication Fork Analysis
- Human Cell-Based Models
Candidates with research experience related to genome maintenance, DNA damage, chromosome instability, or cancer biology would be particularly well suited to the position.
🌟 What You’ll Gain
- Opportunity to work on an NIH-funded research program.
- Advanced research experience in genome stability and chromosome biology.
- In-depth understanding of Bloom syndrome and BLM helicase biology.
- Experience using human cell-based disease models.
- Training in next-generation sequencing and proteomics.
- Exposure to single-molecule research approaches.
- Opportunity to investigate DNA replication, DNA repair, and genome maintenance mechanisms.
- Opportunity to develop an independent research project.
- Experience identifying potential therapeutic vulnerabilities and targets.
- Opportunity to contribute to publications and collaborative research.
- Experience working within an interdisciplinary research environment at USF.
🏛️ Research Environment
The position is based in the Department of Molecular Biosciences at the University of South Florida (USF) within the Schmidt Laboratory / Chromosome Instability Group.
The laboratory’s research combines molecular biology, cell biology, genetics, biochemistry, and quantitative approaches to understand DNA replication and genome stability.
Researchers will work with human cell-based models of Bloom syndrome while developing expertise in advanced approaches including:
- Next-Generation Sequencing
- Proteomics
- Single-Molecule Approaches
- Molecular Biology
- Cell Biology
- Genome Stability Analysis
The laboratory provides an opportunity to pursue both collaborative and independent research focused on fundamental mechanisms of genome maintenance and disease.
💼 Position Details
Position: Postdoctoral Researcher
Funding: NIH-Funded
Institution: University of South Florida (USF)
Department: Molecular Biosciences
Laboratory: Schmidt Laboratory – Chromosome Instability Group
Principal Investigator: Dr. Kristina Schmidt
Location: Florida, USA
Research Focus: Genome Instability & Chromosome Biology
Major Research Theme: Bloom Syndrome and BLM Helicase
Research Areas: DNA Replication | DNA Repair | Homologous Recombination | Chromosome Instability | Cancer Biology
Advanced Techniques: Next-Generation Sequencing | Proteomics | Single-Molecule Approaches
Position Salary: Not stated in the announcement
📄 How to Apply
Interested candidates should send inquiries directly to:
📩 Application Contact
Dr. Kristina Schmidt
Laboratory: Schmidt Laboratory – Chromosome Instability Group
Department: Molecular Biosciences
Institution: University of South Florida
Email: kschmidt@usf.edu
📌 Subject Line:
“Postdoctoral Position – Genome Instability”
Candidates should highlight their relevant research experience and interest in DNA replication, DNA repair, chromosome biology, genome instability, or related areas.
📅 Key Dates
Application Status: Open
Application Deadline: Not stated in the announcement
Expected Start Date: Not stated in the announcement
Position Funding: NIH-funded
Location: Florida, USA
Application Recommendation: Interested candidates are encouraged to contact the PI directly.
📌 Job Details
Institution: University of South Florida (USF)
Department: Department of Molecular Biosciences
Laboratory: Schmidt Laboratory – Chromosome Instability Group
Principal Investigator: Dr. Kristina Schmidt
Position: Postdoctoral Researcher
Location: Florida, USA
Funding: NIH-funded
Research Area: Genome Stability & Chromosome Biology
Major Research Theme: Bloom Syndrome
Key Topics: BLM Helicase | DNA Replication | DNA Repair | Homologous Recombination | Replication Stress | R-Loops | G-Quadruplexes | Chromosome Instability
Techniques: Molecular Biology | Cell Biology | Next-Generation Sequencing | Proteomics | Single-Molecule Approaches
Required Qualification: PhD
Relevant Fields: Molecular Biology | Cell Biology | Genetics | Biochemistry | Cancer Biology | Related Fields
Salary: Not stated
Start Date: Not stated
Application Deadline: Not stated
Application Mode: Email Inquiry
Application Contact: Dr. Kristina Schmidt
Application Email: kschmidt@usf.edu
Subject Line: Postdoctoral Position – Genome Instability
Category
Postdoctoral Position | Postdoc | Genome Instability | Chromosome Biology | Bloom Syndrome | BLM Helicase | DNA Replication | Cell Biology | Genetics | University of South Florida | NIH Research | USA
🏷️ Tags
#Postdoc #PostdoctoralPosition #GenomeInstability #ChromosomeBiology #BloomSyndrome #BLMHelicase #DNAReplication #DNARepair #HomologousRecombination
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