WhatsApp Channel
Telegram Group
🧬 Postdoctoral Fellow Position | Fondazione Santa Lucia IRCCS – Neuroimmunology Unit
Institution: Fondazione Life – Istituto di Ricerca e Cura Santa Lucia IRCCS
Research Unit: Neuroimmunology Unit
Principal Investigator: Giovanna Borsellino, MD, PhD
📍 Location: Rome, Italy
💼 Position: Postdoctoral Fellow
🔬 Research Area: Neuroimmunology | Multiple Sclerosis | T-Cell Biology | Chronic Neuroinflammation | Immunology | Single-Cell Biology | Transcriptomics
The Neuroimmunology Unit at Fondazione Life – Istituto di Ricerca e Cura Santa Lucia IRCCS, under the supervision of Giovanna Borsellino, MD, PhD, is recruiting a Postdoctoral Fellow for a two-year research fellowship focused on understanding immune mechanisms underlying multiple sclerosis (MS) and chronic neuroinflammation.
The project investigates how antigen-specific and bystander immune responses contribute to MS, with particular interest in how immune cells participate in meningeal inflammatory and lymphoid niches and influence disease progression.
🔬 What You’ll Work On
T-Cell Responses in Multiple Sclerosis
Investigate antigen-specific and bystander T-cell responses involved in multiple sclerosis and neuroinflammation.
Viral Immunity
Study the relationship between viral immunity and immune activation in the context of MS and chronic neuroinflammation.
Chronic Neuroinflammation
Explore cellular and molecular mechanisms contributing to persistent neuroinflammatory responses and disease progression.
Meningeal Immune Niches
Investigate how immune cells participate in meningeal inflammatory and lymphoid niches associated with multiple sclerosis.
Single-Cell & Spatial Analysis
Apply single-cell and spatial approaches to characterize immune-cell populations, cellular states, and their organization within disease-associated environments.
🎯 Your Role
The appointed Postdoctoral Fellow will be responsible for:
- Investigating T-cell responses associated with multiple sclerosis.
- Studying antigen-specific and bystander immune activation.
- Examining mechanisms of chronic neuroinflammation.
- Investigating the role of immune cells in meningeal inflammatory and lymphoid niches.
- Performing high-dimensional flow cytometry experiments.
- Conducting cell sorting and cell culture.
- Designing and performing functional T-cell assays.
- Applying single-cell RNA sequencing approaches.
- Applying T-cell receptor (TCR) sequencing approaches.
- Working with transcriptomic datasets.
- Applying spatial transcriptomics approaches.
- Developing and using 2D and 3D cellular models.
- Collaborating with researchers across immunology, neuroscience, and related disciplines.
🧪 Research Focus
The fellowship focuses on understanding how immune responses contribute to multiple sclerosis and chronic neuroinflammation.
The major areas of work include:
- Multiple sclerosis
- Neuroimmunology
- T-cell biology
- Antigen-specific immune responses
- Bystander immune activation
- Viral immunity
- Chronic neuroinflammation
- Meningeal inflammation
- Lymphoid niches
- Immune-cell interactions
- Disease progression
- Single-cell biology
- Transcriptomics
- Spatial transcriptomics
- Cellular models
A central focus is understanding how antigen-specific and bystander immune responses contribute to MS and how immune cells interact within disease-associated meningeal environments.
🔬 Key Methods & Technologies
The successful candidate will have the opportunity to work with a range of advanced experimental approaches, including:
High-Dimensional Flow Cytometry
Characterize immune-cell populations and phenotypes using multiparameter flow cytometry.
Cell Sorting & Culture
Perform immune-cell isolation, sorting, and culture for downstream functional studies.
Functional T-Cell Assays
Investigate T-cell responses and functional properties using cellular immunology assays.
Single-Cell RNA/TCR Sequencing
Characterize cellular states and T-cell receptor repertoires at single-cell resolution.
Transcriptomics
Analyze gene-expression programs associated with immune activation and neuroinflammation.
Spatial Transcriptomics
Study the spatial organization and molecular characteristics of immune cells within relevant tissue environments.
2D/3D Cellular Models
Develop and apply cellular models to investigate mechanisms of neuroinflammation and immune-cell interactions.
👨🔬 Ideal Candidates
Applicants should have:
- A PhD in:
- Immunology
- Cell Biology
- Or a related field
- Strong interest in neuroimmunology and multiple sclerosis research.
- Experience in experimental biomedical research.
- Good scientific and analytical skills.
- Ability to work independently and collaboratively.
- Strong motivation to investigate mechanisms of immune-mediated disease.
⭐ Desirable Experience
Experience in one or more of the following areas is desirable:
- Flow cytometry
- T-cell biology
- Cell culture
- Single-cell approaches
- Immunology
- Transcriptomics
- Molecular and cellular biology
Candidates with experience across multiple techniques relevant to cellular immunology and single-cell analysis may be particularly suited to the interdisciplinary nature of the project.
🧬 Research Questions
The research program addresses several important questions related to MS and neuroinflammation:
- How do antigen-specific T-cell responses contribute to multiple sclerosis?
- What role does bystander immune activation play in disease?
- How does viral immunity influence immune responses associated with MS?
- How do immune cells participate in meningeal inflammatory and lymphoid niches?
- Which cellular and molecular mechanisms contribute to chronic neuroinflammation?
- How do immune-cell populations and their molecular states change during disease progression?
- What can single-cell and spatial approaches reveal about the organization of immune responses in MS?
🏢 Research Environment
The position is based within the Neuroimmunology Unit at Fondazione Life – Istituto di Ricerca e Cura Santa Lucia IRCCS in Rome.
The research environment brings together expertise in neuroimmunology, cellular immunology, neuroscience, molecular biology, and advanced genomic approaches, providing an interdisciplinary setting for investigating mechanisms of multiple sclerosis and neuroinflammation.
The Postdoctoral Fellow will work under the supervision of Giovanna Borsellino, MD, PhD, and contribute to research focused on understanding immune mechanisms associated with MS.
🌟 What You’ll Gain
- Advanced research experience in neuroimmunology.
- Hands-on exposure to multiple sclerosis research.
- Experience studying T-cell responses and immune activation.
- Training in high-dimensional flow cytometry.
- Experience with cell sorting and immune-cell culture.
- Exposure to functional T-cell assays.
- Experience with single-cell RNA and TCR sequencing.
- Exposure to transcriptomic and spatial transcriptomic approaches.
- Experience with 2D and 3D cellular models.
- Opportunity to investigate chronic neuroinflammation at cellular and molecular levels.
- Experience working in an interdisciplinary research environment.
- Opportunity to contribute to scientific publications and presentations.
- Development of expertise spanning immunology, neuroscience, cellular biology, and genomics.
💼 Position Details
Position: Postdoctoral Fellow
Institution: Fondazione Life – Istituto di Ricerca e Cura Santa Lucia IRCCS
Research Unit: Neuroimmunology Unit
Principal Investigator: Giovanna Borsellino, MD, PhD
Location: Rome, Italy
Duration: 2 Years / 24 Months
Research Area: Neuroimmunology
Primary Fields: Immunology | Cell Biology | Neuroscience | T-Cell Biology
Research Focus: Multiple Sclerosis | Chronic Neuroinflammation
Qualification: PhD in Immunology, Cell Biology, or Related Field
Preferred Experience: Flow Cytometry | T-Cell Biology | Cell Culture | Single-Cell Approaches
Key Methods: High-Dimensional Flow Cytometry | Cell Sorting | Functional T-Cell Assays | Single-Cell RNA/TCR Sequencing | Transcriptomics | Spatial Transcriptomics | 2D/3D Cellular Models
Fellowship Duration: 24 Months
Application Mode: Email
Application Deadline: No fixed deadline stated
📄 How to Apply
Interested candidates should submit:
- CV
- Brief description of research experience
- Brief description of research interests
Applications should be sent to:
Principal Investigator: Giovanna Borsellino, MD, PhD
Email: g.borsellino@hsantalucia.it
Candidates with experience in flow cytometry, T-cell biology, cell culture, and/or single-cell approaches are encouraged to apply.
📅 Key Dates
Application Status: Recruiting
Application Deadline: No fixed deadline stated
Start Date: Not specified
Duration: 24 Months
Location: Rome, Italy
Application: Apply as soon as possible
📌 Job Details
Institution: Fondazione Life – Istituto di Ricerca e Cura Santa Lucia IRCCS
Research Unit: Neuroimmunology Unit
Principal Investigator: Giovanna Borsellino, MD, PhD
Position: Postdoctoral Fellow
Location: Rome, Italy
Duration: 2 Years / 24 Months
Research Focus: Multiple Sclerosis | Neuroinflammation | Neuroimmunology
Research Areas: T-Cell Biology | Viral Immunity | Chronic Neuroinflammation | Meningeal Immune Niches
Qualification: PhD in Immunology, Cell Biology, or Related Field
Preferred Experience: Flow Cytometry | T-Cell Biology | Cell Culture | Single-Cell Approaches
Key Techniques: High-Dimensional Flow Cytometry | Cell Sorting | Functional T-Cell Assays | Single-Cell RNA/TCR Sequencing | Transcriptomics | Spatial Transcriptomics
Cellular Models: 2D / 3D Cellular Models
Application Mode: Email
Application Documents: CV | Research Experience Summary | Research Interests Summary
Application Email: g.borsellino@hsantalucia.it
Application Deadline: No Fixed Deadline Stated
Start Date: Not Specified
Category
Postdoctoral Jobs | Neuroimmunology Jobs | Multiple Sclerosis Research | Immunology Jobs | T-Cell Biology | Cell Biology Jobs | Spatial Transcriptomics | Flow Cytometry | Italy Postdoc Positions | Rome Research Jobs | Biomedical Research
🏷️ Tags
#Postdoc #PostdoctoralFellow #Neuroimmunology #MultipleSclerosis #Immunology #TCellBiology #CellBiology #Neuroscience #FlowCytometry #SingleCellRNA
Follow Biopractify for more & Join our community : https://chat.whatsapp.com/F38FNCU0nfvFCDf1mYJDbm
About The Author
