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🧬 Postdoctoral Position in Organic & Medicinal Chemistry | Université Paris Cité
Institution: Université Paris Cité
Laboratory: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT), UMR8601
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
📍 Location: Paris, France 🇫🇷
💼 Position Available: Postdoctoral Researcher
🔬 Research Areas: Organic Chemistry | Medicinal Chemistry | β-Lactamase Inhibitors | Antibiotic Resistance | Chemical Biology | Drug Discovery | Synthetic Chemistry
The Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT), UMR8601 at Université Paris Cité is seeking a motivated Postdoctoral Researcher to work within the Chemistry of RNAs, Nucleosides, Peptides and Heterocycles team led by Laura Iannazzo.
The project focuses on developing new β-lactamase inhibitors and β-lactams to address antibiotic resistance, particularly resistance driven by Klebsiella pneumoniae carbapenemase (KPC) enzymes.
🔬 What You’ll Work On
Antibiotic Resistance & β-Lactamase Research
The project addresses the growing public-health challenge of antimicrobial resistance (AMR), with a particular focus on bacterial resistance mechanisms involving β-lactamases.
The research will investigate strategies for developing chemical compounds capable of targeting β-lactamase-mediated antibiotic resistance.
A major focus will be on Klebsiella pneumoniae carbapenemases (KPCs), which are important β-lactamase enzymes associated with resistance to carbapenem antibiotics.
🧪 Organic & Medicinal Chemistry
The selected postdoctoral researcher will contribute to the development of new chemical entities through synthetic organic and medicinal chemistry approaches.
Research activities will include:
- Development of synthetic strategies
- Synthesis of β-lactamase inhibitors
- Synthesis of β-lactam compounds
- Expansion of chemical diversity
- Structure-based compound development
- Chemical optimization of potential inhibitors
- Investigation of structure–activity relationships
The project aims to expand the chemical diversity of β-lactamase inhibitors and β-lactams with potential applications in combating antibiotic resistance.
🧬 KPC Mutational Landscape & Resistance Mechanisms
The research will be conducted in collaboration with a broader consortium bringing together expertise in antimicrobial resistance, structural biology, and computational approaches.
The project will investigate the mutational landscape of KPC enzymes to better understand how evolutionary changes influence enzyme activity and resistance.
Research will integrate:
- KPC enzyme mutational analysis
- β-lactamase resistance mechanisms
- Evolutionary constraints
- Chemical inhibitor development
- Structure–activity relationships
- Protein–ligand interactions
This integrated approach will support the identification of β-lactamase inhibitors and β-lactams that can exploit evolutionary constraints of the enzyme and potentially limit the emergence of resistance.
🔬 Structural & Computational Collaboration
The project is part of a multidisciplinary consortium involving expertise in:
- Antimicrobial resistance
- Organic chemistry
- Medicinal chemistry
- X-ray structural analysis
- Computational modeling
- Enzyme biology
- Chemical biology
The selected researcher will work within an interdisciplinary research environment connecting chemistry and biology.
🎯 Ideal Candidates
Applicants should have:
- Strong knowledge of organic chemistry.
- Strong knowledge of medicinal chemistry.
- Experience or strong interest in synthetic chemistry.
- An interest in the interface between chemistry and biology.
- Motivation to work on problems related to antimicrobial resistance.
- Ability to work in an interdisciplinary research environment.
Candidates interested in applying chemical approaches to biologically relevant problems are particularly suited to the project.
⭐ Desirable Research Background
Experience or knowledge in one or more of the following areas would be relevant:
- Organic synthesis
- Medicinal chemistry
- Synthetic methodology
- β-Lactam chemistry
- β-Lactamase inhibitors
- Antibiotic resistance
- Antimicrobial drug discovery
- Chemical biology
- Structure–activity relationship studies
- Protein–ligand interactions
- Computational chemistry
- Structural biology
🌟 What You’ll Gain
- Experience in organic and medicinal chemistry research.
- Research experience addressing antibiotic resistance.
- Exposure to β-lactamase inhibitor development.
- Experience developing new β-lactam-related chemical entities.
- Exposure to interdisciplinary chemistry–biology research.
- Collaboration with researchers working in antimicrobial resistance.
- Opportunities to work alongside structural and computational research approaches.
- Experience investigating enzyme evolution and resistance mechanisms.
- Development of advanced synthetic chemistry skills.
💼 Position Details
Position: Postdoctoral Researcher
Institution: Université Paris Cité
Laboratory: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT)
Research Unit: UMR8601
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
Research Focus: β-Lactamase Inhibitors & β-Lactams
Location: Center of Paris, France 🇫🇷
Contract Duration: 12 Months
Expected Start: Between January and March 2027
Research Area: Organic & Medicinal Chemistry
Application Contact: Laura Iannazzo
🧪 Research Focus
The project focuses on developing chemical strategies to address bacterial antibiotic resistance, particularly resistance associated with β-lactamase enzymes.
The research will focus on:
- β-Lactamase inhibitors
- β-Lactam compounds
- KPC enzymes
- Antibiotic resistance
- Synthetic organic chemistry
- Medicinal chemistry
- Chemical diversity
- Mutational landscapes
- Enzyme evolutionary constraints
- Chemistry–biology interface
The project aims to identify compounds that can target β-lactamase activity while taking into account the evolutionary constraints governing enzyme resistance.
🏛️ Research Environment
The position is based at Université Paris Cité, within the LCBPT (UMR8601) in central Paris.
The researcher will join the Chemistry of RNAs, Nucleosides, Peptides and Heterocycles team and participate in a multidisciplinary consortium combining:
- Organic chemistry
- Medicinal chemistry
- Antimicrobial resistance research
- Enzymology
- X-ray structural studies
- Computational modeling
- Chemical biology
This environment provides an opportunity to work at the intersection of synthetic chemistry, molecular biology, and antimicrobial drug discovery.
📄 How to Apply
Interested candidates should contact:
📧 Laura Iannazzo: laura.iannazzo@u-paris.fr
Applicants should highlight their relevant background in organic and medicinal chemistry, synthetic research experience, and interest in chemistry–biology research.
📌 Job Details
Institution: Université Paris Cité
Laboratory: LCBPT – UMR8601
Research Team: Chemistry of RNAs, Nucleosides, Peptides and Heterocycles
Position: Postdoctoral Researcher
Location: Paris, France 🇫🇷
Research Area: Organic & Medicinal Chemistry
Research Focus: β-Lactamase Inhibitors | β-Lactams | Antibiotic Resistance
Key Target: Klebsiella pneumoniae Carbapenemases (KPC)
Key Research Areas: Synthetic Chemistry | Medicinal Chemistry | Chemical Biology | Antimicrobial Resistance
Contract: 12 Months
Start Date: January–March 2027
Application Deadline: Not stated
Application Contact: Laura Iannazzo
Application Email: laura.iannazzo@u-paris.fr
Category
Postdoctoral Position | Postdoctoral Research Fellowship | Organic Chemistry Jobs | Medicinal Chemistry Jobs | Synthetic Chemistry | Chemical Biology | Antibiotic Resistance | β-Lactamase Research | Drug Discovery | Antimicrobial Research | Université Paris Cité | France Postdoc Jobs | Research Jobs
🏷️ Tags
#PostdocPosition #PostdoctoralResearcher #OrganicChemistry #MedicinalChemistry #SyntheticChemistry #ChemicalBiology #AntibioticResistance #BetaLactamase
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