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🧬 Postdoctoral Fellow Position | Massachusetts General Hospital & Harvard Medical School
Institution: Massachusetts General Hospital (MGH) & Harvard Medical School (HMS)
Research Center: Athinoula A. Martinos Center for Biomedical Imaging
Research Lab: Jacobs Lab
Principal Investigator: Dr. Heidi Jacobs
📍 Location: Boston, Massachusetts, USA
💼 Position Available: Postdoctoral Fellow
🔬 Research Area: Neurochemical Changes in Aging & Neurodegeneration | Magnetic Resonance Spectroscopy | Neuroimaging | Alzheimer’s Disease Research
The Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital and Harvard Medical School is inviting applications for a Postdoctoral Fellow to join the Jacobs Lab, led by Dr. Heidi Jacobs.
The position focuses on investigating neurochemical changes associated with aging and neurodegeneration using magnetic resonance spectroscopy (MRS), functional MRS (fMRS), and combined fMRI-MRS, with applications to the early detection and understanding of Alzheimer’s disease and related neurodegenerative conditions.
🔬 What You’ll Work On
🧠 Neurochemical Changes in Aging & Neurodegeneration
Investigate neurochemical alterations associated with aging and neurodegenerative diseases, with a particular interest in mechanisms relevant to Alzheimer’s disease.
🧲 MRS & fMRS
Apply magnetic resonance spectroscopy (MRS) and functional MRS (fMRS) to study neurochemical changes in the human brain.
🔬 Multimodal Neuroimaging
Integrate MRS/fMRS with structural and functional MRI, PET imaging, and other multimodal approaches.
🧠 Locus Coeruleus Research
Research will include investigation of subcortical nuclei, particularly the locus coeruleus, which is relevant to aging and neurodegeneration.
📊 MRS Data Analysis
Design and optimize MRS experiments, analyze spectroscopic data, and accurately interpret neurochemical changes while considering methodological limitations.
🧪 Multimodal Research
Combine neuroimaging with cognitive assessments, psychological measures, physiological recordings, pupil measurements, and blood-based markers.
🎯 Your Role
The selected Postdoctoral Fellow will be expected to:
- Conduct research on neurochemical changes in aging and neurodegeneration.
- Perform experiments using MRS, fMRS, and/or combined time-resolved fMRI-MRS.
- Optimize MRS sequence parameters and experimental protocols.
- Design tasks and scanning paradigms optimized for fMRS.
- Conduct MRS data acquisition and analysis at 3T and/or 7T MRI.
- Analyze and interpret neurochemical data.
- Integrate fMRS with structural and functional MRI and PET.
- Contribute to multidisciplinary research projects.
- Communicate research findings through scientific presentations and publications.
- Work collaboratively with researchers, students, postdoctoral fellows, and research coordinators.
- Develop research skills relevant to future academic and scientific career opportunities.
🧪 Research Focus
The position focuses on the intersection of neuroimaging, neurochemistry, aging, and neurodegeneration, with emphasis on:
- Magnetic Resonance Spectroscopy (MRS)
- Functional MRS (fMRS)
- fMRI-MRS
- Neurochemical Imaging
- Aging & Neurodegeneration
- Alzheimer’s Disease
- Multimodal Neuroimaging
- Structural MRI
- Functional MRI
- 3T MRI
- 7T MRI
- PET Imaging
- Locus Coeruleus
- Cognitive Neuroscience
- Neuroimaging Data Analysis
- Physiological Measurements
The research environment provides opportunities to combine MRS/fMRS with complementary neuroimaging and behavioral approaches.
👨🔬 Ideal Candidates
Applicants should:
- Hold a PhD in Biomedical Physics, Medical Physics, Biomedical Engineering, Neuroimaging, Cognitive Neuroscience, or a related discipline.
- Have hands-on experience with MRS, fMRS, and/or combined time-resolved fMRI-MRS.
- Have experience with MRS sequence parameter optimization.
- Have experience with task design optimized for fMRS.
- Have experience with MRS data acquisition and/or analysis at 3T and/or 7T MRI.
- Demonstrate strong programming skills in Python and/or MATLAB.
- Be able to critically evaluate and interpret neurochemical imaging data.
- Demonstrate strong communication and interpersonal skills.
- Be capable of working independently while contributing effectively within a collaborative research environment.
- Have a strong interest in aging and neurodegenerative disease research.
⭐ Preferred Skills & Experience
Experience in the following areas will be highly relevant:
- Magnetic Resonance Spectroscopy
- Functional MRS
- fMRI-MRS
- 3T MRI
- 7T MRI
- Neuroimaging
- Neurochemical Imaging
- MRS Sequence Optimization
- MRS Data Analysis
- Python
- MATLAB
- Signal Processing
- Cognitive Neuroscience
- Alzheimer’s Disease Research
- Aging & Neurodegeneration
- Structural & Functional MRI
- PET Imaging
- Multimodal Neuroimaging
- Locus Coeruleus Research
- Cognitive Assessments
- Physiological Measurements
🌟 What You’ll Gain
- Opportunity to conduct research at the Martinos Center for Biomedical Imaging.
- Experience in MRS, fMRS, and fMRI-MRS.
- Exposure to 3T and 7T MRI research.
- Experience integrating MRS with MRI and PET imaging.
- Opportunity to investigate neurochemical changes in aging and neurodegeneration.
- Exposure to multidisciplinary Alzheimer’s disease research.
- Opportunities to work with researchers across neuroimaging, neuroscience, and biomedical science.
- Individualized mentoring and professional development within the Jacobs Lab.
- Experience in a highly collaborative research environment at Massachusetts General Hospital and Harvard Medical School.
🏛️ Research Environment
The position is based at the Athinoula A. Martinos Center for Biomedical Imaging, located at Massachusetts General Hospital and affiliated with Harvard Medical School in Boston, Massachusetts.
The successful fellow will join the Jacobs Lab, led by Dr. Heidi Jacobs, and work within a multidisciplinary research environment investigating aging, neurodegeneration, and Alzheimer’s disease using advanced neuroimaging and neurochemical approaches.
The lab’s research integrates MRS/fMRS, MRI, PET, cognitive assessments, physiological measurements, and other multimodal approaches to better understand neurodegenerative processes.
💼 Position Details
Position: Postdoctoral Fellow
Institution: Massachusetts General Hospital (MGH) & Harvard Medical School
Research Center: Athinoula A. Martinos Center for Biomedical Imaging
Research Lab: Jacobs Lab
Principal Investigator: Dr. Heidi Jacobs
Location: Boston, Massachusetts, USA
Research Area: Neurochemical Changes in Aging & Neurodegeneration
Primary Techniques: MRS | fMRS | fMRI-MRS | MRI | PET
MRI Platforms: 3T and 7T MRI
Programming: Python | MATLAB
Research Focus: Aging | Neurodegeneration | Alzheimer’s Disease | Neurochemical Imaging | Locus Coeruleus
PhD Requirement: Biomedical Physics | Biomedical Engineering | Neuroimaging | Cognitive Neuroscience | Related Discipline
Start Date: ASAP, negotiable
Application Deadline: 1 December 2026
Review Process: Applications reviewed on a rolling basis
📄 How to Apply
Interested candidates should submit the following documents:
- Curriculum Vitae (CV)
- Cover letter
- Contact information for three professional references
Applications will be reviewed on a rolling basis until 1 December 2026.
📩 Application Contact
Dr. Heidi Jacobs
Email: hjacobs@mgh.harvard.edu
Applicants should include their relevant research experience, particularly experience in MRS/fMRS, MRI, neuroimaging, and data analysis, in their application materials.
📅 Key Dates
Application Status: Open
Start Date: ASAP, negotiable
Application Deadline: 1 December 2026
Review: Rolling basis
Location: Boston, Massachusetts, USA
📌 Job Details
Institution: Massachusetts General Hospital & Harvard Medical School
Research Center: Athinoula A. Martinos Center for Biomedical Imaging
Lab: Jacobs Lab
Principal Investigator: Dr. Heidi Jacobs
Position: Postdoctoral Fellow
Location: Boston, Massachusetts, USA
Start Date: ASAP, negotiable
Application Deadline: 1 December 2026
Review: Rolling basis
Qualification: PhD in Biomedical Physics, Biomedical Engineering, Neuroimaging, Cognitive Neuroscience, or Related Discipline
Research Areas: Neurochemical Imaging | Aging | Neurodegeneration | Alzheimer’s Disease | Cognitive Neuroscience
Primary Techniques: MRS | fMRS | fMRI-MRS | 3T MRI | 7T MRI | PET
Programming Skills: Python | MATLAB
Preferred Experience: MRS/fMRS | MRS Sequence Optimization | MRS Data Analysis | Multimodal Neuroimaging | Neurodegenerative Disease Research
Required Documents: CV | Cover Letter | Contact Information for Three Professional References
Application Mode: Email
Application Email: hjacobs@mgh.harvard.edu
Application Deadline: 1 December 2026
Category
Postdoctoral Fellowship | Postdoc Position | Neuroimaging | Magnetic Resonance Spectroscopy | fMRS | fMRI-MRS | Cognitive Neuroscience | MGH | Harvard Medical School | Martinos Center | Boston USA
🏷️ Tags
#Postdoc #PostdoctoralFellowship #PostdoctoralPosition #Neuroimaging #MRS #fMRS #fMRI #AlzheimersResearch #Neurodegeneration #CognitiveNeuroscience
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