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🧬 Postdoctoral Researcher Position | Uppsala University
Institution: Uppsala University – Department of Immunology, Genetics and Pathology
📍 Location: Uppsala, Sweden
💼 Position: Postdoctoral Researcher
🔬 Research Area: Functional TP53 Biology | Leukemia | Precision Medicine | CRISPR/Cas9 | Cancer Biology | Genomics | High-Content Imaging | Computational Biology
Uppsala University is seeking a highly motivated Postdoctoral Researcher to join an interdisciplinary leukemia/TP53 research program. The project focuses on understanding how specific TP53 alterations influence leukemia cell behavior, treatment response, and resistance, using genetically defined leukemia models and advanced experimental and computational approaches.
The successful candidate will work at the intersection of molecular and cellular cancer biology, CRISPR-based genome editing, therapeutic profiling, imaging, and computational analysis to investigate TP53-driven mechanisms relevant to precision oncology.
🔬 What You’ll Work On
CRISPR/Cas9 Genome Editing
Build genetically defined, isogenic leukemia cell models representing different TP53 states, including:
- Wild-type (WT)
- Heterozygous
- Homozygous
- TP53-null models
Functional Cancer Biology
Investigate how different TP53 alterations affect:
- Proliferation
- Cell-cycle control
- Apoptosis
- Senescence-like states
- DNA-damage responses
- Genomic stability
- Stress adaptation
Therapeutic Profiling
Study leukemia responses and resistance mechanisms to different therapeutic strategies, including:
- Chemotherapy
- Venetoclax-based combinations
- Hypomethylating agents
- DNA-damaging agents
- Irradiation
- Targeted therapies
High-Content Imaging & Computational Analysis
Apply high-content imaging and quantitative analysis to investigate cellular phenotypes and contribute to the development of computational approaches for TP53 variant classification.
🎯 Your Role
The appointed researcher will be responsible for:
- Developing and characterizing genetically defined leukemia models.
- Performing CRISPR/Cas9 genome editing and validation.
- Studying the functional consequences of specific TP53 mutations.
- Conducting molecular and cellular assays to investigate leukemia phenotypes.
- Performing proliferation, cell-cycle, apoptosis, senescence, and DNA-damage assays.
- Investigating cellular responses to therapeutic treatments.
- Conducting therapeutic sensitivity and resistance profiling.
- Performing high-content imaging and quantitative image analysis.
- Contributing to computational and machine-learning approaches for TP53 variant classification.
- Applying appropriate experimental controls and maintaining rigorous laboratory documentation.
- Collaborating with molecular geneticists, bioinformaticians, and clinical collaborators.
- Analyzing experimental data and contributing to scientific interpretation.
- Preparing manuscripts, presentations, and research reports.
- Contributing to the development of new experimental and computational approaches in precision oncology.
🧪 Research Focus
The position focuses on understanding how TP53 alterations influence leukemia biology and treatment response.
The major areas of work include:
- TP53 biology
- Leukemia models
- Precision oncology
- CRISPR/Cas9 genome editing
- Isogenic cell models
- Cancer cell biology
- Functional genomics
- Therapeutic response and resistance
- Chemotherapy response
- Venetoclax combinations
- Hypomethylating agents
- DNA-damaging agents
- High-content imaging
- Quantitative image analysis
- Machine learning
- TP53 variant classification
- Computational biology
- Molecular and cellular assays
The project combines experimental and computational approaches to address how specific TP53 alterations influence clinically relevant cellular phenotypes and treatment responses.
👨🔬 Ideal Candidates
Applicants should have:
- A PhD in molecular biology, cell biology, cancer biology, hematology, genetics, genomics, or a related field.
- Strong expertise in molecular and cellular biology.
- Experience with mammalian cell culture and cellular assays.
- Experience with CRISPR/Cas9 genome editing is highly desirable.
- Experience in leukemia, cancer, hematopoietic, or related disease models is advantageous.
- Knowledge of functional genomics and/or computational biology.
- Experience with molecular and cellular assays.
- Familiarity with high-content imaging and quantitative analysis is advantageous.
- Ability to work independently as well as collaboratively.
- Strong analytical, problem-solving, and scientific communication skills.
- Ability to contribute effectively to interdisciplinary research projects.
Experience in leukemia or hematopoietic models, CRISPR-based editing, cancer genomics/transcriptomics, image-based analysis, or computational biology is particularly welcome.
🌟 What You’ll Gain
- Hands-on experience in precision oncology research.
- Advanced exposure to TP53 biology and leukemia research.
- Practical experience with genetically defined cancer models.
- Experience with CRISPR/Cas9 genome editing.
- Exposure to therapeutic response and resistance studies.
- Experience with high-content imaging and quantitative image analysis.
- Exposure to computational and machine-learning approaches for cancer research.
- Opportunity to work with molecular geneticists and bioinformaticians.
- Collaboration with clinical researchers and leukemia/TP53 experts.
- Experience contributing to manuscripts and high-impact research projects.
- Opportunity to work in an interdisciplinary research environment at Uppsala University.
💼 Position Details
Position: Postdoctoral Researcher
Department: Department of Immunology, Genetics and Pathology
Institution: Uppsala University
Location: Uppsala, Sweden
Duration: Full-time, 2 years + possible 1-year extension
Reference: UFV-PA 2026/2523
Research Area: Functional TP53 Biology | Leukemia | Precision Medicine
Key Skills: CRISPR/Cas9 | Cancer Biology | Molecular Biology | Cell Biology | Functional Genomics
Additional Skills: High-Content Imaging | Quantitative Analysis | Computational Biology | Machine Learning
📄 How to Apply
Interested candidates should submit their application through the Uppsala University recruitment system.
Applications should include the required application materials and be submitted through the official university recruitment portal.
Application Portal:
Uppsala University – Varbi Recruitment Portal
Reference: UFV-PA 2026/2523
📅 Key Dates
Application Deadline: As specified in the official recruitment portal
Position Duration: 2 years + possible 1-year extension
Employment: Full-time
Location: Uppsala, Sweden
📌 Job Details
Institution: Uppsala University
Department: Immunology, Genetics and Pathology
Position: Postdoctoral Researcher
Employment Type: Full-Time
Location: Uppsala, Sweden
Duration: 2 Years + Possible 1-Year Extension
Qualification: PhD in Molecular Biology, Cell Biology, Cancer Biology, Hematology, Genetics, Genomics, or a related field
Research Areas: TP53 Biology | Leukemia | Precision Medicine | Cancer Biology | Functional Genomics
Key Techniques: CRISPR/Cas9 | Cell Culture | Molecular & Cellular Assays | High-Content Imaging
Computational Areas: Quantitative Image Analysis | Machine Learning | TP53 Variant Classification | Computational Biology
Therapeutic Areas: Chemotherapy | Venetoclax Combinations | Hypomethylating Agents | Targeted Therapies
Reference: UFV-PA 2026/2523
Application Mode: Online
Application Portal: Apply through Uppsala University
Category
Postdoctoral Jobs | Uppsala University Jobs | Cancer Biology Jobs | Leukemia Research | TP53 Research | Precision Oncology | CRISPR Jobs | Molecular Biology Jobs | Cell Biology Jobs
🏷️ Tags
#UppsalaUniversity #Postdoc #PostdoctoralResearcher #TP53 #Leukemia #CancerBiology #PrecisionOncology #CRISPR #CRISPRCas9 #MolecularBiology #CellBiology
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