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🧬 Two-Year Postdoctoral Fellow Position in Adipose Tissue Pathophysiology – INSERM / Sorbonne University
Institution: INSERM / Sorbonne University 🇫🇷
Research Center: Saint Antoine Research Centre (CRSA)
Research Team: Lipodystrophies, metabolic and hormonal adaptations, and aging
Project: ELDORADO Clinical Trial – Metabolic Sub-study
📍 Location: Paris, France 🇫🇷
💼 Position: Postdoctoral Fellow
⏳ Duration: 24 months
📅 Start Date: 1 January 2027
The Saint Antoine Research Centre (CRSA), INSERM / Sorbonne University, is offering a two-year postdoctoral fellowship in adipose tissue pathophysiology.
The successful candidate will work on the metabolic sub-study of the international ELDORADO clinical trial, which compares the effects of two HIV antiretroviral treatment regimens on adipose tissue distribution and function.
The postdoctoral researcher will join the team “Lipodystrophies, metabolic and hormonal adaptations, and aging”, led by Pr B. Fève, and will work with Pr V. Béréziat and Dr C. Lagathu, with Pr J. Capeau as emeritus professor.
🔬 Research Project
The project focuses on understanding the effects of antiretroviral treatment on adipose tissue phenotype, distribution, morphology, and function in people with HIV.
The research will involve:
- Characterization of adipose tissue phenotype from biopsies.
- Analysis of gene expression and global transcriptome.
- Investigation of adipose tissue function.
- Comparison of doravirine/tenofovir/lamivudine and dolutegravir/tenofovir/emtricitabine or lamivudine treatment regimens.
- Analysis of adipose tissue quantity and quality.
- Evaluation of adipose tissue distribution, morphology, and histology.
- Investigation of mechanisms underlying antiretroviral-associated weight gain.
- RNA-seq and transcriptomic analysis.
- Preclinical validation of mechanisms identified through the clinical study.
🧪 What You’ll Work On
1️⃣ Adipose Tissue Characterization
The postdoctoral researcher will characterize adipose tissue samples obtained from participants with HIV initiating antiretroviral treatment.
Key activities will include:
- Analysis of adipose tissue phenotype.
- Gene expression studies.
- Evaluation of tissue function.
- Histological and morphological characterization.
- Investigation of adipose tissue quantity and quality.
2️⃣ Molecular & Cellular Biology
The project will involve molecular and cellular approaches to investigate treatment-associated changes in adipose tissue.
Techniques may include:
- qPCR.
- Western blotting.
- Immunofluorescence.
- Cellular and molecular biology techniques.
- Imaging and tissue analysis.
3️⃣ Transcriptomics & RNA-seq
The researcher will contribute to the analysis of global transcriptomic changes associated with antiretroviral treatment.
This will include:
- RNA-seq analysis.
- Gene-expression profiling.
- Identification of molecular pathways associated with weight gain.
- Interpretation of transcriptomic data.
4️⃣ Comparative Antiretroviral Analysis
The project will compare the effects of different antiretroviral regimens on adipose tissue, particularly focusing on:
- Adipose tissue distribution.
- Tissue morphology.
- Histology.
- Tissue dysfunction.
- Metabolic consequences.
- Treatment-associated weight gain.
5️⃣ Preclinical Validation
Mechanisms identified through the ELDORADO clinical trial will be further investigated through preclinical approaches to understand the biological mechanisms underlying antiretroviral-associated weight gain.
🎯 Ideal Candidates
Applicants should have a PhD in cell biology, molecular biology, biochemistry, or a related field, with strong practical skills in cellular and molecular biology.
Candidates should possess:
- A PhD in cell biology, molecular biology, biochemistry, or a related discipline.
- Strong experience in cellular and molecular biology techniques.
- Practical laboratory research experience.
- Experience with molecular and cellular analysis.
- Ability to work independently and as part of a multidisciplinary research team.
- Strong interest in adipose tissue biology, metabolism, or pathophysiology.
⭐ Skills & Experience
Essential Skills
- Cell biology.
- Molecular biology.
- Biochemistry.
- Cellular and molecular techniques.
- qPCR.
- Western blotting.
- Immunofluorescence.
- Imaging.
- Tissue analysis.
Desirable Skills
- Experience with RNA-seq / transcriptomics.
- Adipose tissue biology.
- Metabolic research.
- Histology.
- Gene-expression analysis.
- HIV research.
- Antiretroviral treatment research.
- Preclinical experimental approaches.
Note: Experience with RNA-seq/transcriptomics is appreciated.
🌟 What You’ll Gain
- Advanced research experience in adipose tissue pathophysiology.
- Hands-on experience with cellular and molecular biology techniques.
- Exposure to clinical translational research.
- Experience working with human adipose tissue samples.
- Training in gene-expression and transcriptomic approaches.
- Experience with RNA-seq and molecular pathway analysis.
- Exposure to HIV and antiretroviral treatment research.
- Experience investigating mechanisms of treatment-associated weight gain.
- Collaboration within an interdisciplinary research environment at INSERM and Sorbonne University.
💼 Position Details
Position: Postdoctoral Fellow
Project: ELDORADO – Metabolic Sub-study
Institution: INSERM / Sorbonne University
Research Center: Saint Antoine Research Centre (CRSA)
Research Team: Lipodystrophies, metabolic and hormonal adaptations, and aging
Location: Paris, France 🇫🇷
Contract: Full-time, 24 months
Start Date: 1 January 2027
Salary: €60,100–€80,700 gross annual salary, depending on experience
Research Focus: Adipose Tissue Pathophysiology | Metabolism | HIV | Antiretroviral Treatment
Key Topics: Adipose Tissue | Gene Expression | RNA-seq | Transcriptomics | Weight Gain | Metabolic Adaptation
📄 Candidate Requirements
Academic Background: PhD in Cell Biology, Molecular Biology, Biochemistry, or related field
Experience: Strong research experience in cellular and molecular biology
Required Skills: Cellular & Molecular Biology | qPCR | Western Blot | Immunofluorescence | Imaging
Preferred Knowledge: RNA-seq | Transcriptomics | Adipose Tissue Biology | Metabolism
Personal Qualities: Motivation | Research Independence | Teamwork | Interest in Translational Research
RNA-seq Experience: Appreciated
📩 How to Apply
Interested candidates should submit their application by email.
Applicants should send:
- CV
- Motivation Letter
- Contact Details of the Project PIs
📧 Scientific Contacts
Claire Lagathu: claire.lagathu-lafon@sorbonne-universite.fr
Véronique Béréziat: veronique.bereziat@sorbonne-universite.fr
Email Subject: “Postdoc ELDORADO – Adipose Tissue”
📅 Application Deadline
Deadline: Not specifically stated in the advertisement.
Candidates are encouraged to apply as soon as possible for the 1 January 2027 start date.
📌 Job Details
Institution: INSERM / Sorbonne University
Research Center: Saint Antoine Research Centre (CRSA)
Research Team: Lipodystrophies, metabolic and hormonal adaptations, and aging
Position: Postdoctoral Fellow
Project: ELDORADO Clinical Trial – Metabolic Sub-study
Location: Paris, France 🇫🇷
Contract: Full-time, 24 months
Start Date: 1 January 2027
Salary: €60,100–€80,700 gross/year
Research Area: Adipose Tissue Pathophysiology | Metabolism | HIV
Research Topics: Adipose Tissue | Gene Expression | Transcriptomics | RNA-seq | Weight Gain | Antiretroviral Treatment
Required Background: PhD in Cell Biology | Molecular Biology | Biochemistry | Related Field
Required Skills: Cellular & Molecular Biology | qPCR | Western Blot | Immunofluorescence | Imaging
Desirable: RNA-seq | Transcriptomics | Adipose Tissue Biology | Metabolic Research
Application Documents: CV | Motivation Letter | PI Contact Details
Application Method: Email
Email Subject: Postdoc ELDORADO – Adipose Tissue
Scientific Contacts: claire.lagathu-lafon@sorbonne-universite.fr | veronique.bereziat@sorbonne-universite.fr
Application Deadline: Not Stated
Category
Postdoctoral Positions | Postdoc Jobs | Cell Biology Jobs | Molecular Biology Jobs | Biochemistry Jobs | Adipose Tissue Research | Metabolism Research | HIV Research | INSERM Jobs | Sorbonne University | France Jobs | Research Jobs
🏷️ Tags
#Postdoc #PostdoctoralPosition #PostdocJobs #CellBiology #MolecularBiology #Biochemistry #AdiposeTissue #Metabolism #HIVResearch
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